Report of death on Letairis due to Liver toxicity

[Anonymous]

It would be ironic if what saves Tracleer market share is the removal of the black box for Letairis. Reliable information from University of Utah is that a cardiologist had a patient who died on Letairis who had LIVER failure! Not good!

Gilead medical and legal have been hounding the hospital, the pathologist and the MD involved. Now watch the Actelion spin machine spring into action.

[Anonymous]

It would be ironic if what saves Tracleer market share is the removal of the black box for Letairis. Reliable information from University of Utah is that a cardiologist had a patient who died on Letairis who had LIVER failure! Not good!

Gilead medical and legal have been hounding the hospital, the pathologist and the MD involved. Now watch the Actelion spin machine spring into action.


People die from liver failure during heart failure on ERA's all the time. Whether or not the drug caused liver failure is another question that has been adequately answered.

UT rep, BTW not Gilead

[Anonymous]

People die from liver failure during heart failure on ERA's all the time. Whether or not the drug caused liver failure is another question that has been adequately answered.

UT rep, BTW not Gilead

Above statement is true, but the patient had LFT elevations greater than 8 X ULN on Tracleer and thus switched to Letairis. Maybe not the right thing to do, but upon autopsy therei was no sign of scirrossis. The autopsy report attributed the death to Letairis.

The black box removal was not a good decision by the FDA. It maybe harmful to patients in the long run.

[Anonymous]

Above statement is true, but the patient had LFT elevations greater than 8 X ULN on Tracleer and thus switched to Letairis. Maybe not the right thing to do, but upon autopsy therei was no sign of scirrossis. The autopsy report attributed the death to Letairis.

The black box removal was not a good decision by the FDA. It maybe harmful to patients in the long run.

Just wait till the FDA finds Actelions stash of AE reports they have been hiding (i mean collecting?) in San Fran. I dont know of any other company that does not report at least yearly. How far back do those unreported AE reports go anyway? Spin Spin Spin!

[Anonymous]

Above statement is true, but the patient had LFT elevations greater than 8 X ULN on Tracleer and thus switched to Letairis. Maybe not the right thing to do, but upon autopsy therei was no sign of scirrossis. The autopsy report attributed the death to Letairis.

The black box removal was not a good decision by the FDA. It maybe harmful to patients in the long run.

You are an idiot. You just admitted Tracleer DILI killed a patient.....stay off the board you moron
You cant even spell Cirrhosis!

[Anonymous]

People die from liver failure during heart failure on ERA's all the time. Whether or not the drug caused liver failure is another question that has been adequately answered.

UT rep, BTW not Gilead

UT, Gileqd, same thong in my book.

[Anonymous]

People die from liver failure during heart failure on ERA's all the time. Whether or not the drug caused liver failure is another question that has been adequately answered.

UT rep, BTW not Gilead

Dear UT and or Gilead rep..who cares which one,

You do not have ANY inside info regarding this so please refrain from your unsolicited comments and opinions.

This is going to take a while for all the medical facts to be collected and sorted out.

However, it is the attending physicians medical opinion that counts. Also, the autopsy report will be presented.
So hold your uneducated opinion.

[Anonymous]

People die from liver failure during heart failure on ERA's all the time. Whether or not the drug caused liver failure is another question that has been adequately answered.

UT rep, BTW not Gilead

They "die ALL the time on ERA's." Wow, not true, you PGI2 pushing UT rep. What a joke. Know your data dumba$$.

[Anonymous]

You guys are HILARIOUS! Painting AMB as liver toxic will get you nowhere.

Can anyone on this board tell me what the % rate of LFT abnormalities greater than 3XULN for Tracleer at:

1 year

2 years



Bueller

Bueller

Didn't think so. Wonder why Actelion has never told us?

[Anonymous]

You guys are HILARIOUS! Painting AMB as liver toxic will get you nowhere.

Can anyone on this board tell me what the % rate of LFT abnormalities greater than 3XULN for Tracleer at:

1 year

2 years
Bueller

Bueller

Didn't think so. Wonder why Actelion has never told us?
Needs no response. Go study.

[Anonymous]

Needs no response. Go study.

You don't know you idiots!

[Anonymous]

I had a KOL tell me there was no way mechanistically that ambrisentan caused LFT tox so I quickly shut up and started talking about booking dinner programs instead. This SUCKS.

[Anonymous]

Original poster must be a bored, stoned teenager online.

[Anonymous]

Original poster must be a bored, stoned teenager online.

LMAO yes teenagers love CP!

[Anonymous]

I had a KOL tell me there was no way mechanistically that ambrisentan caused LFT tox so I quickly shut up and started talking about booking dinner programs instead. This SUCKS.

Oh stop it. The KOLs say that they will test anyway, each month. It's part of the protocol and they don't plan on changing and will still write Tracleer. Some say they disagree with black box removal, not all, but many. The recent "news" of the death of a Letaris patient due to liver failure will be an interesting addition. We need to wait to see all the evidence it will take some time for this to be investigated.

[Anonymous]

Oh stop it. The KOLs say that they will test anyway, each month. It's part of the protocol and they don't plan on changing and will still write Tracleer. Some say they disagree with black box removal, not all, but many. The recent "news" of the death of a Letaris patient due to liver failure will be an interesting addition. We need to wait to see all the evidence it will take some time for this to be investigated.


True

[Anonymous]

Oh stop it. The KOLs say that they will test anyway, each month. It's part of the protocol and they don't plan on changing and will still write Tracleer. Some say they disagree with black box removal, not all, but many. The recent "news" of the death of a Letaris patient due to liver failure will be an interesting addition. We need to wait to see all the evidence it will take some time for this to be investigated.

Oh please. This must be home office chiming in with their delusion of the week.

[Anonymous]

LOL! Agreed!

[Anonymous]

Wow. After only a few short weeks of the black box removal, Letairis is already implicated in a death!? Shame on the FDA. One of just many more Letairis deaths (and elephant leg edema) to come...

[Anonymous]

People die on Letairis all the time. Big difference is that Gilead actually reports these deaths to the FDA. Some other companies...err..ahem..may not..

[Anonymous]

The pts was on Tracleer, but came off due to a rash. The Pts oft level on amb was 12 times the upper limit when taken off. Six week later she died. The interesting part was her LFT level went to normal after coming off amb within 2 weeks, however she died. This is a hard thing for amb and tracleer because this expresses how both ERAs are very toxic. My fear is this will prove PDE-5s are safer and should be used first line!!

O'well!!!

[Anonymous]

Wow. After only a few short weeks of the black box removal, Letairis is already implicated in a death!? Shame on the FDA. One of just many more Letairis deaths (and elephant leg edema) to come...

Well the only reason we have not heard about this happening with tracleer is because you dont actually report your AE's to anyone! Actelion just keeps them in SF so no body know. Wonder how many there are by now?