Hey neurology, if Merck has bailed on their BACE inhibitor, what chance has the Amgen/Novartis molecule have?
Zero chance. Even if the drug works in subjects that have genetic risk, the drug won't work in the larger population of prodromal patients. Sadly, no path forward.
It does not have Sean Harpers blessing so that’s why it failed. Sean talks to God so all things will work.
So often, BB has stated publicly that BACE is a genetically validated target for AD and thus we have a better chance for successful drug discovery and yet here we are, holding a rather expensive shit sandwich.
Psck9 was genetically validated too. But the impact wasn’t as great in the real world. Since when does a banker know science? Sean Harper has a Harvard pedigree but is complete crap.