Let's play "Antibodies for Alzheimers!"

https://medicalxpress.com/news/2019-08-toxic-action-beta-amyloid.html

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5205543/

 

Salt! High-salt diet promotes cognitive impairment through the Alzheimer-linked protein tau

 

is it REALLY this easy? Really?

https://medicalxpress.com/news/2019-12-drugs-quell-brain-inflammation-reverse.html

 

https://medicalxpress.com/news/2020-01-lithium-halt-alzheimer-disease.html

Going small with your chemical entities can sometimes produce amazing results.

 

Another Sola failure! Surprise surprise.

Read the posts in the history of this thread.

So called "AD" has a multifactorial etiology - it's about education, overall health, exercise, blood flow, diet, need I say more?

 

It's getting beyond absurd how much money Lilly keeps pouring down the A-beta rabbit hole.

The original mAb patent was filed in 2002 and has now failed 3 trials, but hey, it's on to EXPEDITION 4?

At what point does management wake up and pull the plug?

 

Sorry, no can do, we got rid of all our chemists.

 

Some very terrible, horrible horrible people say these trials are all about spoofing Wall Street analysts.

That would never happen here.

But seriously, the company basically walks in lock-step with whatever the latest mantra is (like "Antibodies for Alzheimers") -- look back at the history here- still trying to justify a colossal acquisition mistake. Dissent should be encouraged within the ranks. Do something like Google does, have a couple dozen different subsidiaries, let them run with their pet projects.

I've been studying this area for years. It's basically a matter of addressing a dozen or so different targets, and sorry, there is no single magic bullet, and there never will be.

 

May I suggest looking at celastrus paniculatus?

--The Colonel

 

Colonel here again.

Hey you Piled Higher and Deeper types:

Put this in your pipe and smoke it:

https://www.nature.com/articles/s41598-019-45168-1

 

The Case of the Missing Synapses

https://medicalxpress.com/news/2020-02-uncovering-potential-pathway-alzheimer.html

 

"This further emphasises the need for a multi-angle, holistic approach to studying neurodegenerative disease. In order to make breakthroughs, we will have to harness wide-ranging expertise from across the research field, ensuring new knowledge gained is brought together to provide a complete picture of the causes and drivers of dementia."

https://medicalxpress.com/news/2020-03-alzheimer-disease.html

 

https://medicalxpress.com/news/2020-03-brain-doping-body.html

Elegant simplicity.

 

Prevention costs only about $10 (maybe less) per month

https://www.upi.com/Health_News/2020/03/13/Combo-of-heart-drugs-may-also-lower-dementia-risk/3281584124873/?ts_=17

 

Inflammation in the brain may be more widely implicated in dementias than was previously thought, suggests new research from the University of Cambridge. The researchers say it offers hope for potential new treatments for several types of dementia.


Inflammation is usually the body's response to injury and stress—such as the redness and swelling that accompanies an injury or infection. However, inflammation in the brain—known as neuroinflammation—has been recognised and linked to many disorders including depression, psychosis and multiple sclerosis. It has also recently been linked to the risk of Alzheimer's disease.

 

https://medicalxpress.com/news/2020-04-evidence-ultrasound-alzheimer-disease.html

"Our study is the first to look at how the blood-brain barrier cells from human patients can be disrupted to improve the uptake of Alzheimer's therapies, building on previous studies that have explored if ultrasound could be used to reduce amyloid build up in the brains of mice and other animal models."

 

Take your vitamins, kiddo.

 

https://medicalxpress.com/news/2020-07-brain-benefits-gained-protein.html

 

oxytocin

https://medicalxpress.com/news/2020-07-hormone-oxytocin-cognitive-disorders-alzheimer.html