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Anonymous 03-15-2010 09:09 PM

Axiron
 
Lilly Buys Rights to Hormone for Low-Sex-Drive Men (Update1)
March 15, 2010, 6:06 PM EDT

By Rob Waters

March 15 (Bloomberg) -- Eli Lilly & Co., the maker of the impotence pill Cialis, acquired from Acrux Limited a license to commercialize an underarm testosterone lotion for men whose low levels of the hormone leave them with limited sex drive.

Indianapolis-based Lilly will pay Acrux of West Melbourne, Australia, a $50 million license fee plus $3 million when manufacturing assets are transferred, the companies said today in a statement. Acrux may earn $87 million more if U.S. regulators approve the drug for marketing, $195 million in commercial milestone payments as well as royalty payments on future sales, the companies said.

More than a third of American men older than 45 show reduced levels of testosterone, U.S. researchers found in a 2006 study. It can sap sex drive and cause impotence, osteoporosis and memory loss, according to the Mayo Clinic in Rochester, Minnesota. Results of a clinical trial released in September showed Acrux’s lotion, called Axiron, brought testosterone levels to normal in 84 percent of men after four months.

“The addition of Axiron reinforces Lilly’s commitment to men’s health and, if approved, could provide a new treatment option for men suffering from low testosterone,” said Bryce Carmine, president of Lilly’s Bio-Medicines.

Acrux, which has never made a profit, rose 9 cents, or 3.9 percent, to A$2.38 in trading on the Australian stock exchange before the licensing deal was announced. The shares have more than tripled in the past year.

http://www.businessweek.com/news/201...-update1-.html

Anonymous 03-15-2010 09:43 PM

Re: Axiron
 
So why not just take an oral testosterone pill?

Anonymous 03-15-2010 10:31 PM

Re: Axiron
 
they don't exist. Injection or dermal. Acid in stomach not good for Testosterone

Anonymous 01-15-2011 02:01 PM

Re: Axiron
 
So what's up with this product now. Seems like a difficult sell. Not so sure I'm comfortable with this.

Anonymous 01-15-2011 02:04 PM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 3811118)
So what's up with this product now. Seems like a difficult sell. Not so sure I'm comfortable with this.

It doesn't matter. Acrux still can't make the stuff to sell. Why do you think that no one is out there selling right now? Lilly bought a another dead pig in a poke.

Anonymous 01-16-2011 09:43 AM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 3811120)
It doesn't matter. Acrux still can't make the stuff to sell. Why do you think that no one is out there selling right now? Lilly bought a another dead pig in a poke.

this is true. if prduction was not an issue Lilly would have it launched Axiron with Primary Care

Anonymous 01-16-2011 01:38 PM

Re: Axiron
 
actually there are oral forms for testosterone..too many issues with roll ons and orals...axiron will be a great product and theres already alot of talk with physicians who r excited for it to come out..and managers are in the interview hiring process for reps to sell axiron.... reps will promote axiron,cialas. and cymbalta

Anonymous 01-16-2011 01:40 PM

Re: Axiron
 
Another blunder brought to you by the FIPNET strategy. Empowered Heroic BU leadership (DR) making decisions to give hundreds of millions away to another company that can't deliver. Lilly is so desperate that it gives millions away to other companies while it cuts people, salary, merit, and bonus for the people who have the knowledge and know how to save the company. All the while giving a huge bonus to the management that is "saving" the company. What a strategy.

Anonymous 01-17-2011 04:20 PM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 3812025)
this is true. if prduction was not an issue Lilly would have it launched Axiron with Primary Care

this drug doe not stand a chance without primary care. Abbott will crush it

Anonymous 01-18-2011 01:35 AM

Re: Axiron
 
what does abbot have that will crush it

Anonymous 01-18-2011 06:21 AM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 3814391)
what does abbot have that will crush it

Androgel: The #1 topical treatment for "low t". Currently promoted by both Abbott ans Solvay's Primary Care Sales forces.

http://www.pharmalot.com/2010/06/the...-and-androgel/

The Lowdown On Low Testosterone And AndroGel
18 Comments
By Ed Silverman // June 23rd, 2010 // 9:10 am

A new study that finds low testosterone is much less common in older men than previously thought - and is closely identified with just nine specific symptoms - may cause physicians and patients to rethink their use of various elixirs. Take AndroGel, for instance. The salve is cleverly promoted on an unbranded web site called ‘Is It Low T?,’ which features a quiz. The site lists various symptoms and risks purported to be associated with the condition, although some do not match what was noted in the study, which was published last week in The New England Journal of Medicine.

The study found that only 2 percent of men aged 40 to 80 suffer from the condition, which is also called male menopause, andropause or late-onset hypogonadism. The researchers measured testosterone levels in 3,369 men between those ages and then correlated their levels with different symptoms. Of 32 possible symptoms, only nine were linked with decreased testosterone. Three were physical - unable to engage in strenuous activity, walk about a mile or to bend over or kneel - and three were psychological — low energy, sadness and fatigue. However, these six symptoms were only mildly linked to the problem, while three sexual symptoms - less frequent morning erections, low sex drive and erectile dysfunction - were closely related to low testosterone.

“Our results also highlight the substantial overlap between late-onset hypogonadism and non-specific symptoms of aging. The application of these new criteria can guard against the excessive diagnosis of hypogonadism and curb the injudicious use of testosterone therapy in older men,” conclude the researchers, who noted the condition is usually associated with advancing age, yet there is little evidence about the “exact criteria for identifying testosterone deficiency in older men.”

Meanwhile, Abbott’s Solvay Pharmaceuticals unit actively promotes on its site that low testosterone affects more than 13 million men in the US over the age of 45. An Abbott spokesman points to a pair of studies used to bolster the notion that low testosterone will increase substantially with age, including in men well past 65 years old, although these were published in 2004 and 2007 (look here and here). Yet the AndroGel prescribing info acknowledges there haven’t been enough men 65 and older who have participated in clinical trials to know whether the treatment is safe or effective. And it is now 2010. Of course, now that the NEJM study dismisses the notion that older men are more likely to develop the problem, Solvay may not have to conduct a study.

The Low T site also states that the risk of developing low testosterone is 2.4 times greater if one is obese; 2.1 times greater if is one has diabetes; 1.8 greater with high blood pressure and a 1.5 higher risk if one also has high cholesterol. The evidence for this claim comes from this 2006 study. These may be accurate, although for the record, all five authors had ties to Solvay (click on authors and disclosures in the link to the study). Similarly, six of the seven authors of the Endocrine Society Clinical Guidelines for treating low testosterone have ties to Abbott (see page 31). This may confuse some people, since the ‘Low T’ site is identified as a Solvay site. However, a summary of the older version of the guidelines lists financial ties to Solvay (see this).

Also interesting is the pop quiz….


To gauge its usefulness, we deliberately answered ‘no’ to each of the 10 questions, which asked about whether we had lost our libido, energy, strength, height, enjoyment of life, and a few other choice topics. In other words, we deliberately avoided offering any indication that a problem may exist. Just the same, we received this reply: “Your answers show that you have a lower risk for low testosterone (Low T). But it’s still important to talk with your doctor about your symptoms. They may be caused by treatable condition.” What symptoms? Hard to say. Unless one is being pushed to ask a doctor for something.

In response to questions, the spokesman tells us that the site is “designed to simply raise awareness about the condition so that men who believe they’re suffering from the problem can have a conversation with their doctor about it…The quiz is not a diagnostic tool, but is a trigger to have that dialogue with the physician. Someone who takes the quiz may be feeling something isn’t right, so this says that perhaps they should still explore that. But it’s not intended to be diagnostic.”

And what about the site? Will Solvay modify it to reflect the findings from the NEJM study? “We believe there’s plenty of data that would suggest there’s a constellation of symptoms that may be associated with Low T,” he says. “We certainly always encourage continued scientific discovery and continue to look at this, but we still feel sufficient data out there that suggests this whole array of symptoms maybe associated with Low T.”

Anonymous 01-18-2011 06:27 AM

Re: Axiron
 
Androgel

Anonymous 01-18-2011 04:29 PM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 3812025)
this is true. if prduction was not an issue Lilly would have it launched Axiron with Primary Care

pc launch coming...announced today.

Anonymous 01-18-2011 07:49 PM

Re: Axiron
 
Another huge waste of stockholder money. Testosterone deficiency in about 2% of men. I would hazard to guess that much of that may be due to chronic alcoholism.

Anonymous 01-19-2011 06:38 PM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 3815259)
Another huge waste of stockholder money. Testosterone deficiency in about 2% of men. I would hazard to guess that much of that may be due to chronic alcoholism.

But the off label opportunities increase it to 100% of men! Longer unit, more girth, more stamina, staying power, deeper voice for singing in the church choir, increased muscle mass, six pack abs and emission of an animal musk allure that will attract all women within a 12 foot radius (more if down wind!)! Think of the Infomercial "opportunities". Hire a few porn stars to swear to the other benefits and Lilly is on it's way to another blockbuster!

Anonymous 01-24-2011 05:42 PM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 3816420)
But the off label opportunities increase it to 100% of men! Longer unit, more girth, more stamina, staying power, deeper voice for singing in the church choir, increased muscle mass, six pack abs and emission of an animal musk allure that will attract all women within a 12 foot radius (more if down wind!)! Think of the Infomercial "opportunities". Hire a few porn stars to swear to the other benefits and Lilly is on it's way to another blockbuster!

Hmmm. I would buy some. Some good benefits / side effects. Especially the deeper voice for church choir.

Anonymous 02-17-2011 02:01 PM

Re: Axiron
 
When is the Men's Health Unit launching this me-too to Androgel?

Anonymous 03-03-2011 09:00 AM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 3872458)
to all you drug reps who dismiss this, Im a patient who has to use TRT every day & I can tell you we are crying out for a more user friendly form of med! This sounds very promising after having a choice of painful injections that send you on a roller coaster of high then low,
or messy smelly sticky gels that you have to almost cover yourself with - which are too weak ( Androgel) or too sticky (Testim, Tostran)
About time we had some alternatives - might encourage some of your bosses to develop some better products for us! BTW I read its a multi million $ market. Also its very cheap to produce so lots of profits!


I hope you reside in my territory, and not in the Indy Training Department. I'm quite sure this is going to need all the motivation we can scrounge up.

Anonymous 03-03-2011 09:35 AM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 3872559)
I hope you reside in my territory, and not in the Indy Training Department. I'm quite sure this is going to need all the motivation we can scrounge up.

You can recognize him anywhere. Just look for the man with an erect penile one-eyed snake peering at you from above the trouser belt line.

Anonymous 03-08-2011 08:23 PM

Re: Axiron
 
Good luck with this dog... Nothing new here. I have a hard enough time selling Testim and even worse this freakin' Testopel crap is starting to make its mark and we can't even get data on who is using it. Then we have to compete with these dumbasses who use compounded creams on top of that. Saturated market folks.

Anonymous 03-10-2011 12:35 PM

Re: Axiron
 
Axiron targeted marketting:
http://www.funnyordie.com/videos/0b6...nd-dave-franco

Anonymous 03-15-2011 01:55 PM

Re: Axiron
 
So where is Axiron? Why no launch?

Anonymous 04-06-2011 08:51 PM

Re: Axiron
 
So how's it going?!

Anonymous 04-07-2011 12:18 PM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 3881627)

They're optimizing the IRONAX marketing strategy...an example shown above.

Anonymous 06-20-2011 01:38 AM

Re: Axiron
 
The problem now is that major insurance companies, such as Blue Cross Blue Shield of Illinois are instituting dispensing limits for all kinds of drugs, including Androgel and Testim. My husband who has to use 2 Testim patches per day to get his testosterone levels up to normal will, in July, have his insurance cover only one. They claim this is to encourage the use of these drugs "as intended." Still claiming that prescription dosing is still between patient and doctor, they say you can get the amount your doctors prescribes you but you will have to pay for the additional patches. Here in Illinois, that would be $300 per month. My husband was on Androgel but we found that it was sticky, messy, and got all over me, making my testosterone levels go through the roof. The patches alleviated that, but they don't stay on all that well, especially in summer, and leave nasty glue on his body that is painful and difficult to remove. We are hoping that Axiron will take care of the ridiculous, cost-saving cut to his prescription benefit for testosterone supplementation and be less difficult to use while keeping me safe from hormones I don't need.

Anonymous 06-20-2011 01:43 AM

Re: Axiron
 
give me an hour to get you hot

You will not need the androgel, guanteed.

You do use b/c right?

Anonymous 06-20-2011 07:43 PM

Re: Axiron
 
What is the national sales total for this drug? It has to be under 10 scripts, this is by far one of the worst products to hit the market in years

Anonymous 06-22-2011 07:50 PM

Re: Axiron
 
Less than 3 months post launch we are getting 4-5% of the total topical market. Not bad for a "dog."

Anonymous 06-22-2011 07:52 PM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 3987852)
What is the national sales total for this drug? It has to be under 10 scripts, this is by far one of the worst products to hit the market in years

Hey stupid ass so far we have had over 3000 paid rxs filled. A few higher than 10

Anonymous 06-27-2011 04:00 PM

Re: Axiron (Pit Juice)
 
Pit juice represents less than 3% of total market sales as of today, June 27th and your growth rate is already in the decimal places - DOG!!!

66% of pit juice "sales" to date has been FREE PRODUCT (pit juice). I'm not a CEO but that business model isn't going to last too long - DOG!!!

Finally, pit juice is no longer covered by United Healthcare so laydown and play dead, DOG!

The nice man from Australia took your money and ran! What a fraud! HAHA! DOG!!!

Anonymous 07-01-2011 08:29 PM

Re: Axiron
 
you have to give it away - if you weren't giving Free 30 day - no one would touch this ridiculous method of application!

Anonymous 07-01-2011 08:43 PM

Re: Axiron
 
Wow! You sound like an Androgel rep. Little insecure are you? I would be too as we are eating your lunch. This "Dog" sure can hunt. Pretty good for patient to boot!

Anonymous 07-02-2011 05:22 PM

Re: Axiron
 
Market analyst here...looking at the latest data, the Androgel brand does 95X the prescription compared to what Axiron did in the past 13 weeks. Androgel's new low volume formulation alone (which is only 4 weeks old from a promotional standpoint) has almost exceeded Axiron's sales over the past 13 weeks!

I don't see the Axiron market share for topicals in the 4-5% range, more like 0.08% (Androgel, Testim, Axiron, Fortesta).

Axiron works, but so does Striant.

Anonymous 07-06-2011 12:49 AM

Re: Axiron
 
Who cares? Generics kill the market in 1-3 years. Why the fk work my ass off for 2%-10% market share of a dead market. Waste of time. And its runny garbage. I'm embarrassed to sell it.

Anonymous 07-06-2011 06:53 AM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 3987214)
The problem now is that major insurance companies, such as Blue Cross Blue Shield of Illinois are instituting dispensing limits for all kinds of drugs, including Androgel and Testim. My husband who has to use 2 Testim patches per day to get his testosterone levels up to normal will, in July, have his insurance cover only one. They claim this is to encourage the use of these drugs "as intended." Still claiming that prescription dosing is still between patient and doctor, they say you can get the amount your doctors prescribes you but you will have to pay for the additional patches. Here in Illinois, that would be $300 per month. My husband was on Androgel but we found that it was sticky, messy, and got all over me, making my testosterone levels go through the roof. The patches alleviated that, but they don't stay on all that well, especially in summer, and leave nasty glue on his body that is painful and difficult to remove. We are hoping that Axiron will take care of the ridiculous, cost-saving cut to his prescription benefit for testosterone supplementation and be less difficult to use while keeping me safe from hormones I don't need.

Testim is not a patch and is mo messy than Androgel. Your drug is not gonna make it due to your inability to promote it properly. "less transference" I love this one because the FDA will be interested in this tagline, the bad ad people will enjoy this one so be careful. Also, switches to Axiron have been terrified by the complexity of the dosing/application process. What guy wants to wash dishes in the morning after they apply this dripping POS. Its about the patient stupid, make it easier to use not more complicated.

Anonymous 07-06-2011 09:39 AM

Re: Axiron
 
Why not just use porn? It doesn't have application issues at all, and has been used for literally thousands of years. With great success.

Anonymous 07-22-2011 04:26 AM

Re: Axiron
 
Pills will probably be for Clomid or something like it with an indication for males. I don't think they can safely and effectively deliver T orally. So likely it will work by telling your testicles to make more T. More info from your doc would be interesting.

Anonymous 07-23-2011 01:26 AM

Re: Axiron
 
less than 2% market share with any plan.......woof woof, its a dog. new starts are mostly free product...need a new job....

Anonymous 08-04-2011 11:57 AM

Re: Axiron
 
WTF? Who has samples and coupons built into their incentive comp? No one. Patients in my territory are willing to take the freebee but it's not turning into scripts... What a piece of garbage. I'm embarressed to sell it, let alone willing to defend it to the aholes on this board. It's a goofy piece of junk and I'm not going to waste my credibility in the office by jamming it down their throats. I can't wait until launch is over so we can bury this piece of crap.

Anonymous 08-04-2011 04:18 PM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 3815259)
Another huge waste of stockholder money. Testosterone deficiency in about 2% of men. I would hazard to guess that much of that may be due to chronic alcoholism.

That makes no sense at all. I ALWAYS get a huge boner when I am drinking.

Anonymous 08-04-2011 07:00 PM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 4032760)
That makes no sense at all. I ALWAYS get a huge boner when I am drinking.

Me too. Could not count the conquests on several pairs of hands.

Anonymous 08-04-2011 07:05 PM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 4032576)
WTF? Who has samples and coupons built into their incentive comp? No one. Patients in my territory are willing to take the freebee but it's not turning into scripts... What a piece of garbage. I'm embarressed to sell it, let alone willing to defend it to the aholes on this board. It's a goofy piece of junk and I'm not going to waste my credibility in the office by jamming it down their throats. I can't wait until launch is over so we can bury this piece of crap.

I agree 100%. Let's AX this piece of sh1t!

Anonymous 08-05-2011 09:49 PM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 4032658)
That's your response?!? WOW...that's a solid clinical download you just provided. Go back to your bathtub on the beach. Case closed on this dog.

I have a 13.5% SOM! Take that and have a DRINK!

Cheers!

Anonymous 08-06-2011 11:48 PM

Re: Axiron
 
I checked the numbers and no one has 13%, no one even has double digits. You're on crack dude. Unless your territory is someplace in Canada or your definition of market is injectibles only, you're full of crap. FU!

Anonymous 08-18-2011 10:47 AM

Re: Axiron
 
4% SOM here and I'm #1. Best rep in country, baby!

The REAL BIG DOG

Anonymous 08-18-2011 12:48 PM

Re: Axiron
 
Quote:

Originally Posted by Anonymous (Post 4048559)
4% SOM here and I'm #1. Best rep in country, baby!

The REAL BIG DOG

B.S. post. My District (10+ Reps) averaged 4.8% for July! Top Reps in the 20's and 30's SOM for the last weeks of data.

Above post must be the Andro guy still prefers his JIZ all over his hands to rub on Jean amd Bruce!

Anonymous 08-18-2011 09:39 PM

Re: Axiron
 
Funny!

Anonymous 08-18-2011 09:40 PM

Re: Axiron
 
Androgel is only 1%, Axiron is 2%. Axiron has been great for me. 15 days since started and what a difference. Love it!

Anonymous 09-02-2011 02:36 PM

Re: Axiron
 
You Lilly idiots are right, it's easy. It ONLY takes 24 STEPS EVERY DAY to apply properly!!!!!
Hahahaha!!!! WTF!!!! It's on your effin website! Take a pill - 1 step. Use a gel - 3 steps.

http://www.axiron.com/Pages/applying-axiron.aspx

1. Always prime the pump when you open a new bottle of AXIRON. You only need to do this the first time you use it.

2. Gently press the pump 3 times into a sink or toilet. Do not use any of the liquid that came out when you primed.

3. Wash all the liquid thoroughly down the sink to avoid accidental exposure to others.

4. Apply AXIRON at about the same time each morning after showering or bathing. Make sure your underarms are clean and dry with no broken skin and apply it to the underarms only.

5. Do not apply AXIRON to other parts of your body like your stomach, penis, scrotum, shoulders, or upper arms.

6. If you use deodorant or antiperspirant, apply it at least 2 minutes before you apply AXIRON.

7. Hold the nozzle over the applicator cup.

8. Gently press the pump once into the applicator cup. The applicator cup is made to hold 1 pump.

9 Avoid splashing AXIRON in the eyes. In case of contact with eyes, flush thoroughly with water. If irritation persists, seek medical advice.

10. Hold the applicator cup level to keep AXIRON from spilling, and raise it straight up to your underarm. Starting a little above your underarm...

11....and ending a little below your underarm, swipe down and up. If AXIRON drips or runs, wipe it back up with the applicator cup.

12. Do not rub AXIRON with your fingers or hand, and do not rub in the solution with your fingers or hand once it has been applied. Touching the product with your hands may increase the risk of transference to others

13 Apply AXIRON as prescribed by your doctor. Your doctor will determine how many applications are right for you. Check dosing chart.

14. AXIRON is flammable until dry. Let AXIRON dry before smoking or going near an open flame.

15. Rinse the applicator cup with room-temperature running water, pat it dry with a tissue, and discard the tissue safely.

16. Turn the nozzle so that it points away from the label, and place the applicator cup and cap back on the bottle.

17. Store it safely out of the reach of children. To receive child-resistant packaging, call 1-877-9-AXIRON

18. Clean up any spilled solution from surfaces such as the sink or floor to make sure no one else comes in contact with AXIRON.

19. Wash your hands right away with soap and water to help prevent transference to others.

20. Let the application area dry completely before getting dressed. This may take around 3 minutes.

21. Get dressed. Covering your underarms with clothing helps reduce the risk of transfer to others.

22. Keep the area covered until you have washed the application area well or have showered.

23. If you expect another person to have direct skin-to-skin contact with your underarms, first wash the application area well with soap and water.

24. Do not swim or bathe for at least 2 hours after applying AXIRON.

Anonymous 09-02-2011 04:52 PM

Re: Axiron
 
Hey BIG DOG,

Nice job, but are you making any money on that 14% SOM? 10% SOM here and payout was $9,500.
Good day Mr. BIG DOG.
I SAID, "GOOD DAY"!


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