Originally Posted by Anonymous
Regardless, Kanal is Chair of the ACR MR Safety Panel as well as a safety consultant to the FDA. You have to ask yourself this one question, "If you had a child or family member at risk for NSF would you feel comfortable giving them doses of Omniscan?" Period, point blank.
Well, I had an MRI a couple months back, got Omniscan and I lived.
NSF occurs with all agents; why more with Omniscan that others is still a point of contention. Only reason (and I was told this by a Bracco exec) that it didn't occur with ProHance is because you'd throw up if and when you got the dose that much and fast. I'm not a scientist and I've been out of the business since NSF raised its head, but still in touch with folks in the radiology trade and my unscientific reason is that GE spent a lot of time telling us to push Omniscan for high dose, high flow procedures (such as MRA without saying MRA) and we ended up jumping off the cliff when NSF became an issue.
Years back, even doctors were telling us that MRI dye was extremely safe; if you had a patient with high creatine, you could (if you wished, it would be expensive) use doses of MRI contrast for CT, etc. I always had a problem with this ... a drug that you maybe would use 20 mL may act much differently at 100 mL, 150 mL ... But then, I didn't go to medical school and I'd defer to the guy with the medical degree.
Maybe Kanal is a high and mighty safety guru, I won't argue that. But he's been a Bracco paid shrill since God was a kid, and that should have been reported as opposed to just printing the Bracco press release, a trait that seems pretty commonplace in today's "journalism."
And I have NO, ABSOLUTELY, NO love for GE ...