ABRAXANE CREAMS TAXOTERE in MBC

To be presented at SABCS - originally a poster, after greasing Edith Perez's palm we now have an oral presentation - this is going to be BIG!

You manage to take very positive news and make it something negative. First, you are an idiot for sharing confidential information on this board for all of our competitors to see. Second, you are an idiot in not understanding that a company cannot move from having a poster to an oral session by 'greasing' a speaker's palm. That decision is based on the data validity and importance, and is decided by the SABCS group.

Originally Posted by Anonymous

You manage to take very positive news and make it something negative. First, you are an idiot for sharing confidential information on this board for all of our competitors to see. Second, you are an idiot in not understanding that a company cannot move from having a poster to an oral session by 'greasing' a speaker's palm. That decision is based on the data validity and importance, and is decided by the SABCS group.

Dude or duchess, not to be very negative about it but questions are already being raised why this study was done in secrecy in some exotic centers in Eastern Europe or China. Dr PSS pathologically calculating mind reckon that if the study comes out negative, he can always bury it in Siberia or Mongolia and no one will ever see the light of it. While other pharma companies are practicing open disclosure, Abraxis is still hiding in murky deals and caves. Palm greasing is just one dirty tactic.

Originally Posted by Anonymous

You manage to take very positive news and make it something negative. First, you are an idiot for sharing confidential information on this board for all of our competitors to see. Second, you are an idiot in not understanding that a company cannot move from having a poster to an oral session by 'greasing' a speaker's palm. That decision is based on the data validity and importance, and is decided by the SABCS group.

I agree it is crazy for someone to post this---but I LOVE that they did so I'll be looking for this!! Thanks for the inside scoop.

Originally Posted by Anonymous

Dude or duchess, not to be very negative about it but questions are already being raised why this study was done in secrecy in some exotic centers in Eastern Europe or China. Dr PSS pathologically calculating mind reckon that if the study comes out negative, he can always bury it in Siberia or Mongolia and no one will ever see the light of it. While other pharma companies are practicing open disclosure, Abraxis is still hiding in murky deals and caves. Palm greasing is just one dirty tactic.

I agree with you 100%>Edith Perez is one of the biggest whore. Her demands are oftentimes outlandish> Only a Chinese billionnaire can stomach taht.

Originally Posted by Anonymous

Dude or duchess, not to be very negative about it but questions are already being raised why this study was done in secrecy in some exotic centers in Eastern Europe or China. Dr PSS pathologically calculating mind reckon that if the study comes out negative, he can always bury it in Siberia or Mongolia and no one will ever see the light of it. While other pharma companies are practicing open disclosure, Abraxis is still hiding in murky deals and caves. Palm greasing is just one dirty tactic.

Yeah so you've just revealed that you are not with Abraxis or you would know exactly where the study was done and why. It was not due to secrecy (you're still an idiot) but for clinical reasons.

Originally Posted by Anonymous

Yeah so you've just revealed that you are not with Abraxis or you would know exactly where the study was done and why. It was not due to secrecy (you're still an idiot) but for clinical reasons.

Clinical reasons my ass! Look ma, I just pulled out a comparative study vs Taxotere right out of my hat and it is showing superiority! No one knew about this study but suddenly I can shout to the whole world what a great taxane I have! That is not how ethical pharmaceutical companies behave. They announce right off the bat the studies they are doing and reveal results either + or -. You don't hedge your bets and do some secret studies somewhere in Timbuktu with the hope of burying the crime if the results are no good. It is small wonder why the industry reputation stinks.

Originally Posted by Anonymous

Clinical reasons my ass! Look ma, I just pulled out a comparative study vs Taxotere right out of my hat and it is showing superiority! No one knew about this study but suddenly I can shout to the whole world what a great taxane I have! That is not how ethical pharmaceutical companies behave. They announce right off the bat the studies they are doing and reveal results either + or -. You don't hedge your bets and do some secret studies somewhere in Timbuktu with the hope of burying the crime if the results are no good. It is small wonder why the industry reputation stinks.

There were plenty of investigators who knew about this study. Just because Aventis managed to have their head so far up their butts claiming Abraxane wasn't a worthy competitor that they missed that information does not minimize the value of the study! And many study results are held until major medical conferences. It is advance leaking of information like this that causes ASCO to embargo data until the meeting. You do realize how long ago abstracts had to be submitted for SABCS, right?

Or was it just you aventis idiots who were so damn certain we wouldn't be able to show superiority? You've rested on your laurels and were caught with your pants down. Blame your company not mine!

hey Abraxis reps - don't get caught up in this argument. It is clearly aventis looking for more details so they can craft a defense strategy. Keep your mouths shut. Don't do the competition's work for them.

Let the games begin!

Originally Posted by Anonymous

hey Abraxis reps - don't get caught up in this argument. It is clearly aventis looking for more details so they can craft a defense strategy. Keep your mouths shut. Don't do the competition's work for them.

Let the games begin!

we'll see how it goes. abraxis is known for making cross trial comparisons which makes the likes of hudis and gradishar fart to high heavens. abraxis is also known for making grandiose superiority claims based on 30-40 studies, socinski, schiller and greco were laughing at the verbosity and pompousness of soon-shiong and his coterie of bodyguards & ex-aventis ass-lovers.

Originally Posted by Anonymous

we'll see how it goes. abraxis is known for making cross trial comparisons which makes the likes of hudis and gradishar fart to high heavens. abraxis is also known for making grandiose superiority claims based on 30-40 studies, socinski, schiller and greco were laughing at the verbosity and pompousness of soon-shiong and his coterie of bodyguards & ex-aventis ass-lovers.

ahem...based on 30-40 patient studies

Originally Posted by Anonymous

Clinical reasons my ass! Look ma, I just pulled out a comparative study vs Taxotere right out of my hat and it is showing superiority! No one knew about this study but suddenly I can shout to the whole world what a great taxane I have! That is not how ethical pharmaceutical companies behave. They announce right off the bat the studies they are doing and reveal results either + or -. You don't hedge your bets and do some secret studies somewhere in Timbuktu with the hope of burying the crime if the results are no good. It is small wonder why the industry reputation stinks.

I can't wait to see the looks on the dummy's from Aventis's face when they hear Perez tell the world that there taxane just got the shit kicked out of them. There is a logical explanation for the study being done in these institutions and those know nothing reps from Aventis will be running around like chickens with their heads cut off when this hits.

Originally Posted by Anonymous

Clinical reasons my ass! Look ma, I just pulled out a comparative study vs Taxotere right out of my hat and it is showing superiority! No one knew about this study but suddenly I can shout to the whole world what a great taxane I have! That is not how ethical pharmaceutical companies behave. They announce right off the bat the studies they are doing and reveal results either + or -. You don't hedge your bets and do some secret studies somewhere in Timbuktu with the hope of burying the crime if the results are no good. It is small wonder why the industry reputation stinks.

I Aventis wasn't extremely frightened by this data they would not be posting on your website. I will certainly take a very close look at this new data!

Originally Posted by Anonymous

I Aventis wasn't extremely frightened by this data they would not be posting on your website. I will certainly take a very close look at this new data!

Yeah you you will still be looking at the data as we continue to take market share from you. You have a has been product and are not used to having to go up against a biotech company but rather other big pharma companies

Originally Posted by Anonymous

Clinical reasons my ass! Look ma, I just pulled out a comparative study vs Taxotere right out of my hat and it is showing superiority! No one knew about this study but suddenly I can shout to the whole world what a great taxane I have! That is not how ethical pharmaceutical companies behave. They announce right off the bat the studies they are doing and reveal results either + or -. You don't hedge your bets and do some secret studies somewhere in Timbuktu with the hope of burying the crime if the results are no good. It is small wonder why the industry reputation stinks.

I can attest to hearing Amar (remember amar?) say that if the study didn't work out, then the company could bury it. This is a very unethical company.

Originally Posted by Anonymous

I can attest to hearing Amar (remember amar?) say that if the study didn't work out, then the company could bury it. This is a very unethical company.

Yeah, and your testament is very sound on an anonymous board, quoting a former employee who isn't here to contest your remarks.

Who cares to debate whether or not the study would be buried if it had been negative? The FACT is, the study is not negative, so Aventis will be slinging as much mud as they can to try and take focus off the fact that Abraxane will take their market.

Originally Posted by Anonymous

Who cares to debate whether or not the study would be buried if it had been negative? The FACT is, the study is not negative, so Aventis will be slinging as much mud as they can to try and take focus off the fact that Abraxane will take their market.

DUCHESS, I'll bet my ovaries that the data will be similar to the Ph II dose dense study- KINDA hot, VERY V ERY cold, Pazdur , O'shaughenessy didn't even want to touch at it. Nothing conclusive except PiSS's big mouth sucking on Dicknose Montagner OR VV. Your nose is stuck high up into the Chink's ass to know any better except to sing to the Choir of Soon-Shiong's greed. iF PISS ask you to taste his shit, I will bet you will more than gladly oblige.

Originally Posted by Anonymous

DUCHESS, I'll bet my ovaries that the data will be similar to the Ph II dose dense study- KINDA hot, VERY V ERY cold, Pazdur , O'shaughenessy didn't even want to touch at it. Nothing conclusive except PiSS's big mouth sucking on Dicknose Montagner OR VV. Your nose is stuck high up into the Chink's ass to know any better except to sing to the Choir of Soon-Shiong's greed. iF PISS ask you to taste his shit, I will bet you will more than gladly oblige.

You need some serious help - I really mean it. Read this message back to yourself. This type of horrible vindictive tirade comes from some where that contains completely unreasonable anger. I am so sorry for you – but there is help for this type of anguish. I sincerely hope that you are able to find someone to help you.

Originally Posted by Anonymous

You need some serious help - I really mean it. Read this message back to yourself. This type of horrible vindictive tirade comes from some where that contains completely unreasonable anger. I am so sorry for you – but there is help for this type of anguish. I sincerely hope that you are able to find someone to help you.

To OP: a second helping of PSS's shit and your given advice will go a long, long way. May God bless and save your poor misguided soul.

Originally Posted by Anonymous

DUCHESS, I'll bet my ovaries that the data will be similar to the Ph II dose dense study- KINDA hot, VERY V ERY cold, Pazdur , O'shaughenessy didn't even want to touch at it. Nothing conclusive except PiSS's big mouth sucking on Dicknose Montagner OR VV. Your nose is stuck high up into the Chink's ass to know any better except to sing to the Choir of Soon-Shiong's greed. iF PISS ask you to taste his shit, I will bet you will more than gladly oblige.

nOT TO DEFEND THIS LADY'S TIRADE..but there are elements of truth in the post. DD study was being bragged about by Patrick even before the data came out to be the cure all for BC only to fall flat at SABCS. Joyce who is the most enthusiastic speaker is so muted when talking about this study and ODAC laughed at it. The rest you can read in the NYT.
It is no secret what Patrick has done to investors, employees and even his own brother to merit such a negative reaction. This is the reason why he has to surround himself with bodyguards everywhere he goes even at medical meetings such as ASCO. It is also no secret that there are doctors at ASCO who are quite insulted by the presence of bodyguards.

hello, i agree with your reply. britney spears, angelina jolie or bill gates need bodyguards because of their celebrity status. patrick maybe believes that he is also a 'celebrity' or he must have done some grievious harm to people to need this kind of protection. i think it is perverse

Originally Posted by Anonymous

Yeah you you will still be looking at the data as we continue to take market share from you. You have a has been product and are not used to having to go up against a biotech company but rather other big pharma companies

THE BIGGEST "HAS-BEEN" PRODUCT IN THE WORLD IS PACLITAXEL. ABRAXANE IS SIMPLY PAXCLITAXEL. MIKE HAWKINS ADMITTED THIS AT ODAC. DON'T BELIEVE IT? CHECK THE TRANSCRIPT>

Originally Posted by Anonymous

hello, i agree with your reply. britney spears, angelina jolie or bill gates need bodyguards because of their celebrity status. patrick maybe believes that he is also a 'celebrity' or he must have done some grievious harm to people to need this kind of protection. i think it is perverse

this obsession with bodyguards, is this delusion of grandeur or just plain paranoia? with so many lives that patrick has destroyed from employees to investors to his own family, no wonder he needs this protection. i wonder how he sleeps at night, with the bodyguards beside him as well??? or maybe montagner and flannelly sleeps besides him everynight,

Abraxane RR = 44%
Taxotere RR = 20%
p=0.042

FY SA

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Abraxane RR = 44%
Taxotere RR = 20%
p=0.042

FY SA

=what bonus and for whom?

Alert P4! We need programs, programs, programs designed to promote off-label WEEKLY high dose Abraxane. Expect a flood of these post-San Antonio. Budget to come from Patrick's bodyguard slush fund.

Originally Posted by Anonymous

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Abraxane RR = 44%
Taxotere RR = 20%
p=0.042

FY SA

=what bonus and for whom?

same old story. based on ph II Bosnian study with 50 patients each arm and drawing grand conclusion. no survival or TTP significance, just RR and edith perez and the Chink proclaiming God's miracle. heard that story before.
By the way, I like the post about the bodyguards. Blum said it makes Patrick looks sexier.

Originally Posted by Anonymous

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Abraxane RR = 44%
Taxotere RR = 20%
p=0.042

FY SA

=what bonus and for whom?

This is going to be so BIG!!! I can't wait to see the looks on all of my physicians faces when they come back from SABC and we talk about this. This is just validation of what we have been saying all along. Now is the time that we have to stay strong and take our drug to the next level. I hope that data like this will help us all regain our focus because the best is yet to come

Originally Posted by Anonymous

This is going to be so BIG!!! I can't wait to see the looks on all of my physicians faces when they come back from SABC and we talk about this. This is just validation of what we have been saying all along. Now is the time that we have to stay strong and take our drug to the next level. I hope that data like this will help us all regain our focus because the best is yet to come

The study will be great but do you think this is enough for a $350M quota for next year?

No change in indication, no compendia, no reimbursement. This will mean nothing !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

Let's see how Gradisher tries to spin statistical sense out of a 300 patient, four arm study in which 30% of patients have not even been evaluated for response. Read the abstract. And then I want to see the O'Shaughnessies and Sledges of oncology line up behind it. And then, I want to see Rumplestiltskin spin straw into gold. And then I want to eat the little bear's porridge and live happily ever after.

How long have you people been selling in oncology. RR doesn't mean dick. If you can't show a survival advantage or at least a TTP advantage, what have you done for the patient? Your drug sucks. It's just another Taxane and its cost is not justified.

Your all wasting your time. You would be smart to get out while you still can.

Originally Posted by Anonymous

Let's see how Gradisher tries to spin statistical sense out of a 300 patient, four arm study in which 30% of patients have not even been evaluated for response. Read the abstract. And then I want to see the O'Shaughnessies and Sledges of oncology line up behind it. And then, I want to see Rumplestiltskin spin straw into gold. And then I want to eat the little bear's porridge and live happily ever after.

Hmmm,phase II 4 arm study, 60 pts in each arm, marginally better RR (p=0.042), no TTP . I wonder what happened in the second Abraxane arm. This is a typical study that the spinmaster, Soon-Shiong, likes to spin as a breakthrough of his nanoparticle. I am really looking fwd to how Gradishar is going to present this study with a straight face knowing that:
1. Just a month ago, he has no clue that the study even existed
2. He can't even pronounce the name of the country in which the study was done even though his ancestry is from Eastern Europe
3. He derides PSS as a charlatan and calls the 'nab' MOA as 'hocus-pocus'
4. He tells everyone (confidentially, of course) that thought leaders like himself are being exploited by PSS who stands to gain billions more from expert endorsement
5. Flannelly and Hogan screwed him big time while they were at Aventis and treated him as second class speaker. He gets constipated just looking at them.

Originally Posted by Anonymous

Hmmm,phase II 4 arm study, 60 pts in each arm, marginally better RR (p=0.042), no TTP . I wonder what happened in the second Abraxane arm. This is a typical study that the spinmaster, Soon-Shiong, likes to spin as a breakthrough of his nanoparticle. I am really looking fwd to how Gradishar is going to present this study with a straight face knowing that:
1. Just a month ago, he has no clue that the study even existed
2. He can't even pronounce the name of the country in which the study was done even though his ancestry is from Eastern Europe
3. He derides PSS as a charlatan and calls the 'nab' MOA as 'hocus-pocus'
4. He tells everyone (confidentially, of course) that thought leaders like himself are being exploited by PSS who stands to gain billions more from expert endorsement
5. Flannelly and Hogan screwed him big time while they were at Aventis and treated him as second class speaker. He gets constipated just looking at them.

Post reminds me of Belani at the Abraxis sympo in Greenspan NYC. Belani looked like he was suffering from acute case of diarrhea while presenting the lung data on Abraxane. Uncomfortable, under the spotlight, he probably was thinking how the hell he got involved in this vodoo stuff. Seidman as usual was his in slick salesman pitch. Someone ought to look into how much these blokes are paid for by Abraxis to do their commercials.

Originally Posted by Anonymous

Post reminds me of Belani at the Abraxis sympo in Greenspan NYC. Belani looked like he was suffering from acute case of diarrhea while presenting the lung data on Abraxane. Uncomfortable, under the spotlight, he probably was thinking how the hell he got involved in this vodoo stuff. Seidman as usual was his in slick salesman pitch. Someone ought to look into how much these blokes are paid for by Abraxis to do their commercials.

I wish all you aventis guys would get the F#@# off our board. Just because all the thought leaders have left you now the whores who don't want to be doing what they are doing? Funny how when they spoke for you guys they were key opnion leaders and now they are whores!

Originally Posted by Anonymous

I wish all you aventis guys would get the F#@# off our board. Just because all the thought leaders have left you now the whores who don't want to be doing what they are doing? Funny how when they spoke for you guys they were key opnion leaders and now they are whores!

Exactly, get those Abrentis executives BF, CM, JH et al, off Abraxis. these are the same people who turned all these thought leaders into whores while they were at Aventis. Patrick must have very deep pocket or zero scruples to have hired these pimps into ABBI

Taxotere has experience in over 10 years, 5 tumor types and 7 indications- PiSS, Dicknose Montagner & Fungal Face Flannelly expect SA to roll over with fear over a ph II marginal study??? Get real. The shit 3rd generation taxane? couldn't even prove survival benefit in 1st line MBC despite 50% more dose.

Time for all these so called KOLs to come clean. Also the incestuous relationships between the major players in the Coop Groups, ASCO, JCO need to be exposed. The FDA and government should insist on full transparency including how much money these "whore KOLs" receive from big pharma annually.

KOL relationships need to be managed by Medical Affairs NOT Marketing. At sanofi-aventis before I left there was an almighty struggle between marketing (Kazmi) and medical (Campbell aka Crocodile Debde). Maybe the time has come for the Feds to put up a firewall between marketing and thought leaders

Originally Posted by Anonymous

Taxotere has experience in over 10 years, 5 tumor types and 7 indications- PiSS, Dicknose Montagner & Fungal Face Flannelly expect SA to roll over with fear over a ph II marginal study??? Get real. The shit 3rd generation taxane? couldn't even prove survival benefit in 1st line MBC despite 50% more dose.

Wow..You sound a little defensive. You must of heard about all the RN's that complain about the nails, and swelling of all those " poor women that have to put up with Taxotere.
You wouldn't be on this board if you weren't a little worried.