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  #1  
Old 01-12-2011, 09:54 PM
Anonymous
 
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Default Victoza and Thyroid Cancer

Much has been said on this board about Victoza causing Thyroid cancer only in rodents with no evidence of the effect in humans and so forth:

Here is an excerpt of section 5.1 of the Victoza PI sheet:

In the clinical trials, there have been 4 reported cases of thyroid C-cell hyperplasia among Victoza®treated patients and 1 case in a comparator-treated patient (1.3 vs. 0.6 cases per 1000 patient-years).One additional case of thyroid C-cell hyperplasia in a Victoza®-treated patient and 1 case of MTC in a comparator-treated patient have subsequently been reported. This comparator-treated patient with MTC had pre-treatment serum calcitonin concentrations >1000 ng/L suggesting pre-existing disease.

And so Victoza may not be dioxin but it certainly ain't roses either.

Let the name calling begin and profanity begin...
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  #2  
Old 01-12-2011, 10:14 PM
Anonymous
 
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Default Re: Victoza and Thyroid Cancer

and did you happen to look at the calcitonin concentrations for the 4 Victoza patients pre-trial? Also high. Clearly, something going on in all these patients prior to the trial. Even the MTC patient on the comparator.

Quit stirring an empty pot.
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  #3  
Old 01-13-2011, 12:48 AM
Anonymous
 
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Default Re: Victoza and Thyroid Cancer

Quote:
Originally Posted by Anonymous View Post
and did you happen to look at the calcitonin concentrations for the 4 Victoza patients pre-trial? Also high. Clearly, something going on in all these patients prior to the trial. Even the MTC patient on the comparator.

Quit stirring an empty pot.
There is no mention of calcitonin concentrations in the 4 Victoza patients - this is because they were normal. If you read the complete paragraph it appears that NN tested every participants' calcitonin pre-trial.

3 more people out of approximately 250 developed thyroid cancer than would have if they were kept off Victoza and this was a relatively short study in comparison to the length of time a person would be expected to be on Victoza. Logically it would be expected that additional thyroid tumors would be revealed in a longer study.
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  #4  
Old 01-14-2011, 11:35 AM
Anonymous
 
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Default Re: Victoza and Thyroid Cancer

Quote:
Originally Posted by Anonymous View Post
There is no mention of calcitonin concentrations in the 4 Victoza patients - this is because they were normal. If you read the complete paragraph it appears that NN tested every participants' calcitonin pre-trial.

3 more people out of approximately 250 developed thyroid cancer than would have if they were kept off Victoza and this was a relatively short study in comparison to the length of time a person would be expected to be on Victoza. Logically it would be expected that additional thyroid tumors would be revealed in a longer study.
check out the epir. it shows the levels were elevated in these patients.
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  #5  
Old 01-16-2011, 10:06 PM
Anonymous
 
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Default Re: Victoza and Thyroid Cancer

Quote:
Originally Posted by Anonymous View Post
There is no mention of calcitonin concentrations in the 4 Victoza patients - this is because they were normal. If you read the complete paragraph it appears that NN tested every participants' calcitonin pre-trial.

3 more people out of approximately 250 developed thyroid cancer than would have if they were kept off Victoza and this was a relatively short study in comparison to the length of time a person would be expected to be on Victoza. Logically it would be expected that additional thyroid tumors would be revealed in a longer study.
wrong. all had elevated levels. do your research.
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  #6  
Old 01-18-2011, 06:29 PM
Anonymous
 
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Default Re: Victoza and Thyroid Cancer

So I thought this may be a good drug to look at for my type 2 .. but reading this here looks like bad stuff to me. I can not afford my Janumet 365.00 a month. I need a good drug for my type 2 any suggestions. I have HORRIBLE side effects with the Metamorfin (sp) or however it is spelled. The Janumet is a bit better but the side effects are still uncomfortable. I have been trolling boards for weeks and my Doctor is an ass and gives no real help. Sees me for 15 min and out the door barely looks me in the face.
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  #7  
Old 01-18-2011, 09:11 PM
Anonymous
 
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Default Re: Victoza and Thyroid Cancer

Quote:
Originally Posted by Anonymous View Post
So I thought this may be a good drug to look at for my type 2 .. but reading this here looks like bad stuff to me. I can not afford my Janumet 365.00 a month. I need a good drug for my type 2 any suggestions. I have HORRIBLE side effects with the Metamorfin (sp) or however it is spelled. The Janumet is a bit better but the side effects are still uncomfortable. I have been trolling boards for weeks and my Doctor is an ass and gives no real help. Sees me for 15 min and out the door barely looks me in the face.
Here's a suggestion: Get off of CafePharma.
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  #8  
Old 01-19-2011, 12:31 PM
Anonymous
 
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Default Re: Victoza and Thyroid Cancer

Quote:
Originally Posted by Anonymous View Post
Here's a suggestion: Get off of CafePharma.
Yes, this is only for people who know for a fact that Victoza does not cause cancer and that the FDA is trying to screw Novo on a wrong basis.
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  #9  
Old 01-19-2011, 11:30 PM
Anonymous
 
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Default Re: Victoza and Thyroid Cancer

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Yes, this is only for people who know for a fact that Victoza does not cause cancer and that the FDA is trying to screw Novo on a wrong basis.
Actually, it's simply an awful place to solicit medical advice.
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  #10  
Old 01-20-2011, 11:30 AM
Anonymous
 
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Default Re: Victoza and Thyroid Cancer

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Actually, it's simply an awful place to solicit medical advice.
So right.
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  #11  
Old 01-20-2011, 09:51 PM
Anonymous
 
Posts: n/a
Default Re: Victoza and Thyroid Cancer

Quote:
Originally Posted by Anonymous View Post
Much has been said on this board about Victoza causing Thyroid cancer only in rodents with no evidence of the effect in humans and so forth:

Here is an excerpt of section 5.1 of the Victoza PI sheet:

In the clinical trials, there have been 4 reported cases of thyroid C-cell hyperplasia among Victoza®treated patients and 1 case in a comparator-treated patient (1.3 vs. 0.6 cases per 1000 patient-years).One additional case of thyroid C-cell hyperplasia in a Victoza®-treated patient and 1 case of MTC in a comparator-treated patient have subsequently been reported. This comparator-treated patient with MTC had pre-treatment serum calcitonin concentrations >1000 ng/L suggesting pre-existing disease.

And so Victoza may not be dioxin but it certainly ain't roses either.

Let the name calling begin and profanity begin...
Ok, I'll call it..... "Soon to be a blockbuster" - how's that?
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  #12  
Old 01-21-2011, 09:42 AM
Anonymous
 
Posts: n/a
Default Re: Victoza and Thyroid Cancer

Quote:
Originally Posted by Anonymous View Post
Ok, I'll call it..... "Soon to be a blockbuster" - how's that?
Fuckbuster, I'll go along with that.
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