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  #1  
Old 05-09-2011, 09:16 PM
Anonymous
 
Posts: n/a
Rant Victrelis

I thought we were supposed to get approval 2 weeks before those douche bags at Vertex, which would be today. If we don't get it tomorrow should I be worried?
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  #2  
Old 05-09-2011, 09:18 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

you should be worried that you don't know what you're talking about and there is no way you work here
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  #3  
Old 05-09-2011, 09:25 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

I do work here dumbass and given that we got hammered by the FDA about our DDI or rather lack there of we should all be concerned!
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  #4  
Old 05-10-2011, 01:09 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Why don't you tell all of us your territory so everyone will know who it is that doesn't know the date we are supposed to get approval. Thanks
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  #5  
Old 05-10-2011, 01:11 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
I do work here dumbass and given that we got hammered by the FDA about our DDI or rather lack there of we should all be concerned!
Ya we got so hammered by the FDA A.C. that they gave us an 18-0 vote
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  #6  
Old 05-10-2011, 08:35 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

18-0 is nice but ever hear of something called delayed approval
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  #7  
Old 05-11-2011, 03:03 PM
Anonymous
 
Posts: n/a
Banghead Re: Victrelis

Lousy drug, soon come the layoffs...
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  #8  
Old 05-12-2011, 10:30 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

We should have approval tomorrow, Monday at the latest. Probably not going to see approval for NR though.
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  #9  
Old 05-13-2011, 08:28 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

There might be some time needed for adjusting the labeling based on the panel's considerations. Merck's labeling issues probably will be more complex than will be Vertex's because of the patient populations they both hoped to reach and their product's respective side effects.
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  #10  
Old 05-13-2011, 01:06 PM
Anonymous
 
Posts: n/a
Lol Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
We should have approval tomorrow, Monday at the latest. Probably not going to see approval for NR though.
Guessing game, this is what everyone at Vertex is saying, funny haha.
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  #11  
Old 05-13-2011, 03:18 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Both will get approved and there will be too much risk of political heat for the approvals to be delayed much past the known PDUFA date (23rd May for Vertex). Even if Victrelis were approved next Monday, it would only get a 1-week head start. If one or the other is delayed for label issues that the other does not have, it will be a marketing problem for the delayed compound. No apparent reason for them not to be approved on the same day.
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  #12  
Old 05-13-2011, 05:02 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

JUST GOT APPROVED!!
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  #13  
Old 05-13-2011, 11:45 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Hey, here is an idea, how about you Victrelis reps try not to be negative on this board at this time. This is a great time for you, the PI looks pretty good, you have a FIRST in class and probably best in class drug. Now go be a sales person who is confident in your product and sell some drug and help some patients. You don't need to be negative now, you have no reason to be. Partner with your docs, they will need you and will want to see you. You have the total package. This is a good time, be proud and hold your head up high, I an't imagine that Genentec and Vertex can't give the service you can give.
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  #14  
Old 05-14-2011, 12:05 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
Hey, here is an idea, how about you Victrelis reps try not to be negative on this board at this time. This is a great time for you, the PI looks pretty good, you have a FIRST in class and probably best in class drug. Now go be a sales person who is confident in your product and sell some drug and help some patients. You don't need to be negative now, you have no reason to be. Partner with your docs, they will need you and will want to see you. You have the total package. This is a good time, be proud and hold your head up high, I an't imagine that Genentec and Vertex can't give the service you can give.
Ditto this--it is such a fantastic opportunity to have a first in class launch, you will never have the opportunity to make these types of calls again--no doubt you are well prepared, go have some fun. Nothing better than launch with a solid PI and patients that need a product to help them live a healthier life. Quit bitching for a brief moment and enjoy what so few of us get to do these days.
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  #15  
Old 05-14-2011, 10:02 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
Ditto this--it is such a fantastic opportunity to have a first in class launch, you will never have the opportunity to make these types of calls again--no doubt you are well prepared, go have some fun. Nothing better than launch with a solid PI and patients that need a product to help them live a healthier life. Quit bitching for a brief moment and enjoy what so few of us get to do these days.
Yeah, go ahead and live it up for one whole week. It will feel good to be relevant for a while
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  #16  
Old 05-15-2011, 08:54 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

This approval is the culmination of what the industry is supposed to be - develop and sell new therapies meeting unmet medical needs. Not a bunch of me-too and combo therapies. Sad that these days come around so infrequently.
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  #17  
Old 05-15-2011, 09:42 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Something good came from SPRI!!!
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  #18  
Old 05-15-2011, 12:11 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
This approval is the culmination of what the industry is supposed to be - develop and sell new therapies meeting unmet medical needs. Not a bunch of me-too and combo therapies. Sad that these days come around so infrequently.
I agree, very exciting. SPRI was a good research organization (as was Organon), better batting average than most of their peers. I have no contact with Sales, Marketing or Research. Most of my info for these products have come from the internet, just an interested back office employee.

I've been following this drug for six years and even in the Hassan days they were pretty quiet about it (unlike TRA). Vertex on the other hand did not pass up an opportunity to put out a press release. They seem to be a half venture capital, half pharma company. Similar to Pfizer.

While Tel seems to have better cure rates the rash issue could be huge. Vertex's decision to go it alone with the US commercialization is also a big risk for them. We have an entrenched and talented Hep sales force, Managed Care team experienced in this field and probably a lower price. From the job postings over at Vertex, they still seem to be putting together a launch plan... IMO

Like the previous posters have mentioned it's nice to have a bit of good news on the novel treatment front. Good luck to those who will be selling it (Not a bad place to be)!
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  #19  
Old 05-17-2011, 01:10 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Roche is going to sell this product - what happens to Peg Intron and the Merck sales force?
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  #20  
Old 05-17-2011, 03:16 PM
Anonymous
 
Posts: n/a
Lol Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
Roche is going to sell this product - what happens to Peg Intron and the Merck sales force?
Well Merck....it's about time that you realized that Genentech/Roche knew how to sell better than you. You reps must be feeling pretty pathetic right now...first we kick your ass with Pegasys and now we need to come rescue you with boceprevir. I'm personally not looking forward to this, but I'll log my calls and promote the best PI on the market...and unfortunately its not yours. I do think this is hilarious and will be profitable for Genentech - I'm sure this deal is worth millions.

To previous poster - I would say that your HCV field force is in extreme trouble. If your management doesn't have confidence in your own ability and you have to "hire" your competition to sell a brand new product, then your fate is pretty much sealed!
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  #21  
Old 05-17-2011, 05:13 PM
Anonymous
 
Posts: n/a
Angry Re: Victrelis

I'm right there with you. My Merck rep is a douchebag and can't believe the loser is still around! Now I have to go help him after all these years? This just gives him more of a reason to stay home and doing nothing! Schering and now Merck reps have NEVER been good to work with! And based on their share, offices don't care for them either. I'm just waiting to hear these losers talk about this venture! So Merck, what do you have to say?????
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  #22  
Old 05-17-2011, 05:35 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Shame on Merck and Genentech. When you go to bed with dogs you get up with fleas.
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  #23  
Old 05-17-2011, 06:27 PM
Anonymous
 
Posts: n/a
Jester Re: Victrelis

Merck Enlists Roche's Help To Promote New Hepatitis Drug - Headline from the Wall Street Journal. Congrats Merck Reps. You must be so proud we Genetech reps have to come in and do your job for you.
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  #24  
Old 05-17-2011, 11:48 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

The jealousy from the vertex reps whose company couldn't close their own deal is a joke. And yes it's obvious this is from vertex reps cause this deal isn't just about sales of Victrelis. It's much much more.

Many companies co promote and i look fwd to working with my Genentech counterpart. We respect each other and will have a great working relationship because we are professionals not children.
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  #25  
Old 05-18-2011, 12:31 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

While Merck maybe be spinning the positive long term benefits of this arrangement, don't let your arrogance blind you to the fact we are being called upon to do your job. We have dominated in the interferon market. While it's great you play nice with your rep, don't expect the rest of the field force to be excited about making education calls on your behalf to move your product we when are already blowing out Pegasys. It also doesn't change the fact Vertex has a better product. That's reality not jealousy.
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  #26  
Old 05-18-2011, 12:58 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

The better product is the one that has the safety and efficacy. Is shorter treatment worth it when there is rash, anemia and discontiuation rates that are high. Then I guess pushing a treatment that doesn't work for the majority of patients is why Genentech chose to copromote with the better drug. All the studies with Telaprevir were done with Pegasys and Genetech chose Merck because Victrelis is a better drug in the long run for patients- they make it through treatment and they don't have rash clinics.
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  #27  
Old 05-18-2011, 01:18 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

so answer me a question:

telap is considered a better drug. Why? Top line SVR was 79% and SOC was 46%. That's a 1.71 fold improvement over SOC

Bocep top line SVR is 66% with SOC at 38%. That's a 1.73 fold improvement over SOC.

why is telap better?
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  #28  
Old 05-18-2011, 01:21 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
While Merck maybe be spinning the positive long term benefits of this arrangement, don't let your arrogance blind you to the fact we are being called upon to do your job. We have dominated in the interferon market. While it's great you play nice with your rep, don't expect the rest of the field force to be excited about making education calls on your behalf to move your product we when are already blowing out Pegasys. It also doesn't change the fact Vertex has a better product. That's reality not jealousy.
so if Vertex would have signed an agreement with Genentech for the same thing would you be on the Vertex board posting the same crud?

BTW, I truly hope you don't detail bocep, your unaided recall comes back crappy and you miss out on 30% of your bonus.
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  #29  
Old 05-18-2011, 01:22 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
so answer me a question:

telap is considered a better drug. Why? Top line SVR was 79% and SOC was 46%. That's a 1.71 fold improvement over SOC

Bocep top line SVR is 66% with SOC at 38%. That's a 1.73 fold improvement over SOC.

why is telap better?
NOW THAT'S REALITY
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  #30  
Old 05-18-2011, 01:22 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

I'll answer this question...it's because telap + pegasys is the better combo champ. PegIntron SOC 38% says it all...
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  #31  
Old 05-18-2011, 08:15 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
so answer me a question:

telap is considered a better drug. Why? Top line SVR was 79% and SOC was 46%. That's a 1.71 fold improvement over SOC

Bocep top line SVR is 66% with SOC at 38%. That's a 1.73 fold improvement over SOC.

why is telap better?
Too easy! because in Victrelis study- "SOC" was not SOC- it was PegIntron. That's like saying your a "10" when you're in a beauty contest with Rosie ODonnell.
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  #32  
Old 05-18-2011, 09:09 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Merck knows that the Peg Intron future is not as bright as the boceprevir future. The next generation of therapies will look to minimize exposure to ribavirin and interferon. They choose to try to win in the short term at tela versus bocep at the price of Intron. It is about ganging up on Vertex. Roche is in this deal probably because they only have Pegasys in the game at the present and might have been spurned by Vertex. And which therapy will consume more Pegasys? The short telaprevir or the the longer boceprevir? If Merck does not show good Victrelis numbers, the stock price will take a hit; Nobody will look too hard at the PegIntron numbers - the total is unlikely to go down even as the market share might. The best specialists will go with the combo that showed the best results for cure (Pegasys plus telaprevir). The majority of the prescribers will follow the path that has dictated their prescribing patterns historically. Hype, money, and pressure will move sales with that lot.
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  #33  
Old 05-18-2011, 10:07 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
so answer me a question:

telap is considered a better drug. Why? Top line SVR was 79% and SOC was 46%. That's a 1.71 fold improvement over SOC

Bocep top line SVR is 66% with SOC at 38%. That's a 1.73 fold improvement over SOC.

why is telap better?
This is a PERFECT example of why Roche/Genentech continues to kick your ass! "So Dr., I'm here to promote the new PI. And just to let you know, our delta difference is .02 percent better than Vertex. Now isn't that important to tell your patients? Never mind that 79% SVR is the highest in the marketplace, our delta is greater! And yes, we used PegIntron as our peg of choice because it has less than a 20% market share!"

PLEASE GOD....I can't work with these douchebags!!!!!!
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  #34  
Old 05-18-2011, 10:11 AM
Anonymous
 
Posts: n/a
Jester Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
The jealousy from the vertex reps whose company couldn't close their own deal is a joke. And yes it's obvious this is from vertex reps cause this deal isn't just about sales of Victrelis. It's much much more.

Many companies co promote and i look fwd to working with my Genentech counterpart. We respect each other and will have a great working relationship because we are professionals not children.
Genentech here...This is pretty funny....must be Merck upper sales management because this is NOT what we are hearing from your salesforce or ours. And face it, the reason we're "working" with you has nothing to do with the drug...it has to do with the $25 million + you are paying us! Boy, I bet the Merck reps wish that that money was going into their incentive plan....sorry Merckies....it's coming to us.
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  #35  
Old 05-18-2011, 12:46 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Vertex is gonna kick our butt. That's unavoidable.
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  #36  
Old 05-18-2011, 01:00 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Vertex and Merck will both come out on top in this one. It is largely a new business with warehoused patients. The rumored price of therapy is so high that gross margins will be 85% or greater. Insurance companies and the state/fed governments will pick up the tab. Question will be how much gets spent or how much price gets discounted in order to win the war.
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  #37  
Old 05-19-2011, 12:20 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

I do love how one disgruntled, miserable person posts several times to try to make us believe that the entire Roche field force is so up in arms about this deal. I, for one, don't buy it.
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  #38  
Old 05-19-2011, 12:25 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

miserable, bitter people. I feel for your families and loved ones. In a few months we'll see where market share falls, until then the bile will flow all over this board. Very very sad.
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  #39  
Old 05-19-2011, 12:50 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
I do love how one disgruntled, miserable person posts several times to try to make us believe that the entire Roche field force is so up in arms about this deal. I, for one, don't buy it.
You, as one of many, will be unemployed in January.
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  #40  
Old 05-19-2011, 02:47 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
I do love how one disgruntled, miserable person posts several times to try to make us believe that the entire Roche field force is so up in arms about this deal. I, for one, don't buy it.
Ask your Genetech rep if you don't believe it. While we are forced to provide docs with Victrelis information, we are still competing with you on Peg sales. Or more accurately, you are competing with us. We get to help you while your contracting team continues to to go after our managed contracts. Sorry we're not as giddy as you think we should be.
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  #41  
Old 05-19-2011, 09:05 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
I do love how one disgruntled, miserable person posts several times to try to make us believe that the entire Roche field force is so up in arms about this deal. I, for one, don't buy it.
Sorry Todd...but get your fat head out of the office and take a listen around the entire COUNTRY! If people say they're happy about this, they say it because they're up your ass comfortably living. Genentech is NOT happy either. I'm beginning to believe that this 2 year deal has something much more behind it....say Genentech taking over the entire division from Merck, grabbing HCV drug development, and imploding the Merck sales force. You said it yourself Toad, Merck has no confidence in the sales force.
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  #42  
Old 05-20-2011, 12:40 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
Sorry Todd...but get your fat head out of the office and take a listen around the entire COUNTRY! If people say they're happy about this, they say it because they're up your ass comfortably living. Genentech is NOT happy either. I'm beginning to believe that this 2 year deal has something much more behind it....say Genentech taking over the entire division from Merck, grabbing HCV drug development, and imploding the Merck sales force. You said it yourself Toad, Merck has no confidence in the sales force.
I'm just happy that I'm not friends with anyone that is this bitter and miserable. Someone must know who this is. If they are this miserable on CP then they are miserable about everything else in their life
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  #43  
Old 05-20-2011, 12:48 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
This is a PERFECT example of why Roche/Genentech continues to kick your ass! "So Dr., I'm here to promote the new PI. And just to let you know, our delta difference is .02 percent better than Vertex. Now isn't that important to tell your patients? Never mind that 79% SVR is the highest in the marketplace, our delta is greater! And yes, we used PegIntron as our peg of choice because it has less than a 20% market share!"

PLEASE GOD....I can't work with these douchebags!!!!!!
You are really retarded. The 79% means the improvement over the STANDARD OF CARE- is a 28-30% higher SVR. Telaprevir doesn't get to 79% without 2 other drugs in the regimen and you have to look at the DELTA change. OMG seriously good luck if that's what you think. Maybe you even think the FDA didn't pull out a class effect of ANEMIA in Telaprevir. Both drugs have the SAME delta over Standard of CARE- peg/rbv and BOTH drugs have ANEMIA... Pull your head out of ASS.
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  #44  
Old 05-20-2011, 12:53 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
Sorry Todd...but get your fat head out of the office and take a listen around the entire COUNTRY! If people say they're happy about this, they say it because they're up your ass comfortably living. Genentech is NOT happy either. I'm beginning to believe that this 2 year deal has something much more behind it....say Genentech taking over the entire division from Merck, grabbing HCV drug development, and imploding the Merck sales force. You said it yourself Toad, Merck has no confidence in the sales force.
Genentech seems fine with the co-promote. I talked to my Roche/Genentech rep yesterday. They are happy to help out and happy to have something new. They are also primarily focused on Pegasys, but they aren't disgruntled why would they be? Todd may not get along with a few reps and managers, but that is life- not everyone gets along. Personally, I think Todd has been doing a great job and pulling together an improved marketing, sales management team from what we have been used to in the past. Enjoy the happy times. Anyone can buy out a division... maybe we'll continue co-promoting the HCV treatments together with Genentech, maybe we'll get bought out. Either way, there are many HCV drugs in the pipeline and there is a lot of talk about BMS, BI, and other companies with improved HCV drugs without Peg/RBV...
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  #45  
Old 05-20-2011, 02:20 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

It is clear that Merck and Roche having some form of a deal concerning HCV will already raise the spectre of collusion to corner the market for one portion of the SOC, pegylated interferon. The promotion deal may be a taunt to see if Vertex rises to the bait to call in the feds to investigate when in fact it might only be for ensuring that Roche does not actively distribute sales material for telaprevir and thereby exclude boceprevir. There is absolutely no chance that one or the other company will solely promote these therapies to by the agreement of both and to the exclusion of one or the other. Once telaprevir is appproved, look ot see if Vertex will enter in some marketing agreement with Roche to distribute information to their contacts just like Merck did.
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  #46  
Old 05-20-2011, 09:40 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
You are really retarded. The 79% means the improvement over the STANDARD OF CARE- is a 28-30% higher SVR. Telaprevir doesn't get to 79% without 2 other drugs in the regimen and you have to look at the DELTA change. OMG seriously good luck if that's what you think. Maybe you even think the FDA didn't pull out a class effect of ANEMIA in Telaprevir. Both drugs have the SAME delta over Standard of CARE- peg/rbv and BOTH drugs have ANEMIA... Pull your head out of ASS.
Ask a patient if they care about the delta difference or a 79% SVR over a 63% SVR. If you look at Pegasys trials, you will see that the control arm is consistent in what you see in other Pegasys trials. Merck had higher rates in the control arm in the Pegasys BVR trial is well.
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  #47  
Old 05-20-2011, 11:09 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

No offense meant to Victrelis but if I had HCV, I would put my money on Pegasys and telaprevir based on the numbers that have been published. For now, that combination has not been topped by PegIntron plus boceprevir. And I wouldn't give a damn what my doctor or his sales might recommend to the contrary.
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  #48  
Old 05-21-2011, 11:59 AM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Ya you're right. who cares what their doctor might think or recommend. RETARD
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  #49  
Old 05-21-2011, 12:51 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

The importance and effect of the Pharma sales force is most crucial during a launch. I've heard one Sr. Manager say that launch is the only time a sales force is worth the cost.

This is a great move in my opinion. The Roche, SP (Merck) reps have been competing for a long time. I hope they can work together because the success of this drug (and your compensation) depends on it.

Would you rather have Roche helping sell the product, or a contract team from Innovex?

Vertex has a good drug, by most accounts better. The rash could be a serious issue however. There are plenty of drugs were efficacy is trumped by side effects (look at ACE v. ARB in HBP).

Either way, good for patients and Hep reps.
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  #50  
Old 05-21-2011, 04:03 PM
Anonymous
 
Posts: n/a
Default Re: Victrelis

Quote:
Originally Posted by Anonymous View Post
Ya you're right. who cares what their doctor might think or recommend. RETARD
The collaboration of pharmaceutical sales and doctors has resulted in some, but not all and one hopes not most, doctors being little better than the fabled car mechanic with respect to recommending therapies that will make the most money for the doctor. When ones life is on the line, whether Hep C or surgery, it pays to educate yourself about the choices and to get second opinions. It just isn't that hard to find the actual data on Hep C. Today, sadly, one sure as hell ought not trust the stereotypical pharma sales rep's (Vertex or Merck or Roche) personal recommendation. Pharma companies have managed to get themselves way down the list of most trusted and they only have themselves to blame. Scrupulous doctors and medical centers are afraid to taint themsleves by means of continuing some of the more disreputable sales relationships of the last 10-15 years. Hep C is likely to apply some of the patient advocacy information sharing that has characterized HIV care. This aggressive patient involvement (as opposed to just blindly following what doctors and pharmas offer) has probably improved the care of HIV overall.
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