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  #1  
Old 11-17-2012, 08:15 AM
Anonymous
 
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Party WHY LINZESS KILLS MICE

Just met with a GI today who saw your booth at the ACG in Las Vegas. He asked, "The Linzess booth didn't have much information. What do you think about your newest competitor?" He was surprised to learn that it has a black box warning and asked why. I told him, "It's because Linzess causes a significant electrolyte imbalance and kills young mice. Just imagine if a patient's children or grand children got ahold of it and ate it. Would you want to take that chance?" He responded that he couldn't believe the FDA would approve a drug that dangerous. Good luck selling the rat poison!
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  #2  
Old 11-17-2012, 09:06 AM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

Quote:
Originally Posted by Anonymous View Post
Just met with a GI today who saw your booth at the ACG in Las Vegas. He asked, "The Linzess booth didn't have much information. What do you think about your newest competitor?" He was surprised to learn that it has a black box warning and asked why. I told him, "It's because Linzess causes a significant electrolyte imbalance and kills young mice. Just imagine if a patient's children or grand children got ahold of it and ate it. Would you want to take that chance?" He responded that he couldn't believe the FDA would approve a drug that dangerous. Good luck selling the rat poison!
Imagine if your wife was unknowingly pregnant, you know the first month or two before most women find out. She then took her Amitiza and your unborn child died as a result of her taking the prostaglandin abortion pill for her IBS. It's a crazy world out there, makes you wonder how many other unborn children died as a result of taking their Amitiza when the mother didn't know she was pregnant.
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  #3  
Old 11-17-2012, 09:07 AM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

Quote:
Originally Posted by Anonymous View Post
Just met with a GI today who saw your booth at the ACG in Las Vegas. He asked, "The Linzess booth didn't have much information. What do you think about your newest competitor?" He was surprised to learn that it has a black box warning and asked why. I told him, "It's because Linzess causes a significant electrolyte imbalance and kills young mice. Just imagine if a patient's children or grand children got ahold of it and ate it. Would you want to take that chance?" He responded that he couldn't believe the FDA would approve a drug that dangerous. Good luck selling the rat poison!
Hey baby killer, I also forgot to say..

I'm sorry you didn't get the job
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  #4  
Old 11-17-2012, 10:39 AM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

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Hey baby killer, I also forgot to say..

I'm sorry you didn't get the job
Uhh, Linzess is pregnancy category C as well.
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  #5  
Old 11-17-2012, 11:12 AM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

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Uhh, Linzess is pregnancy category C as well.
Read your PI amitiza tool boy. Linzess does not cause abortions, nor is a pregnancy test required prior to starting therapy.
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  #6  
Old 11-17-2012, 02:17 PM
Anonymous
 
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Party Re: WHY LINZESS KILLS MICE

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Read your PI amitiza tool boy. Linzess does not cause abortions, nor is a pregnancy test required prior to starting therapy.
If you plan to convince doctors that your Pregnancy Category C drug is safer for women than other Pregnancy Category C drugs- Good luck with that!
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  #7  
Old 11-17-2012, 03:14 PM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

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If you plan to convince doctors that your Pregnancy Category C drug is safer for women than other Pregnancy Category C drugs- Good luck with that!
Again, read your own PI jackass. Amitiza does indeed kill unborn children in guinea pigs!
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  #8  
Old 11-17-2012, 04:42 PM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

Quote:
Originally Posted by Anonymous View Post
Just met with a GI today who saw your booth at the ACG in Las Vegas. He asked, "The Linzess booth didn't have much information. What do you think about your newest competitor?" He was surprised to learn that it has a black box warning and asked why. I told him, "It's because Linzess causes a significant electrolyte imbalance and kills young mice. Just imagine if a patient's children or grand children got ahold of it and ate it. Would you want to take that chance?" He responded that he couldn't believe the FDA would approve a drug that dangerous. Good luck selling the rat poison!
I'm really sorry you didn't get the job. Forest has some open positions and they have many contract sales teams that work with them. Perhaps you should try to work at one of those companies since Ironwood didn't work out for you.
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  #9  
Old 11-17-2012, 10:44 PM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

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Uhh, Linzess is pregnancy category C as well.
The abortifacient activity of lubiprostone is evident in the data from the pregnant guinea pig study. A preliminary range-finding study showed that abortions occurred in 4% of pregnant females at a dose of 5 micrograms per kilogram (g/kg). That study was followed by a second, larger study showing dose-dependent abortions beginning at 1 g/kg. Abortions occurred in 0%, 3.8%, 8.0%, and 19% (0, 1, 10, 25 g/kg) (see Figure 1). There were 22 to 26 pregnant guinea pigs for each dose. The 1 g/kg dose in guinea pigs is approximately the same exposure as the 48 g dose in women.
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  #10  
Old 11-17-2012, 10:51 PM
Anonymous
 
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Party Re: WHY LINZESS KILLS MICE

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Again, read your own PI jackass. Amitiza does indeed kill unborn children in guinea pigs!
C=Linzess=Amitiza= Same safety for women. If you can't make that conclusion then it explains why Takeda fired you during the last layoff and why you had to take the Ironwood job. Good luck selling with a black box warning!
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  #11  
Old 11-17-2012, 11:24 PM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

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I'm really sorry you didn't get the job. Forest has some open positions and they have many contract sales teams that work with them. Perhaps you should try to work at one of those companies since Ironwood didn't work out for you.
Dude, chill with the not getting the job thing. When the recruiter emailed me the drug, I didn't even respond. I'm glad you found a job though, especially since you'll be talking cc and ibs-c, only creating more awareness. But seriously, even if you run the table and put amitiza in the ground, plecanatide is going to bend you over hard. How's your pipeline?
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  #12  
Old 11-18-2012, 03:45 AM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

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Dude, chill with the not getting the job thing. When the recruiter emailed me the drug, I didn't even respond. I'm glad you found a job though, especially since you'll be talking cc and ibs-c, only creating more awareness. But seriously, even if you run the table and put amitiza in the ground, plecanatide is going to bend you over hard. How's your pipeline?
Says the troll that is always posting on a companies site he doesn't work for...LOL
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  #13  
Old 11-18-2012, 03:48 AM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

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C=Linzess=Amitiza= Same safety for women. If you can't make that conclusion then it explains why Takeda fired you during the last layoff and why you had to take the Ironwood job. Good luck selling with a black box warning!

Data from animal reproduction studies performed by Sucampo Pharmaceuticals and submitted to the FDA indicate that pregnant guinea pigs treated with Amitiza at doses two to six times higher than the highest recommended human doses between days 40 and 53 of gestation experienced fetal loss, also known as miscarriage.
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  #14  
Old 11-18-2012, 09:51 AM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

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Says the troll that is always posting on a companies site he doesn't work for...LOL
I work for a REAL GI company, selling UC and Crohns meds. Unlike you, I'm actually a specialty rep and do not call on PCP's. I had a lot of former colleagues come work here, that is why I "troll" this site, as you put it. Just think it is really funny everyone jumped ship to sell a baby killing product.
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  #15  
Old 11-19-2012, 07:22 AM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

Stop with I know you did not get the job.

The fact that these drugs are preg C , so what many drugs are.

The problem will be safer OTC drugs remember Zelnorm.
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  #16  
Old 11-19-2012, 09:58 AM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

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Originally Posted by Anonymous View Post
Stop with I know you did not get the job.

The fact that these drugs are preg C , so what many drugs are.

The problem will be safer OTC drugs remember Zelnorm.
You are an absolute moron. Let me address your 3 points here.

1 - Zelnorm - was not removed due to CV's with women of child bearing age, this happened in elderly patients. Since you sell Amitiza currently, you would know that 95% of docs felt it was BS that Zelnorm was removed in the way that it was.

2 - Pregnancy Cat C, really? You think this means anything? Nobody is suggesting that we will be targeting actual pregnant women for this drug. Millions of women of child bearing age (that is old enough to be pregnant, but not actually pregnant-in case you don't understand what that means) are currently on SSRI therapy, just one example. Here's the big difference between these SSRI's, Linzess and Amitiza. The label for Amitiza states a woman of child bearing age must have a negative pregnancy test and be monitored on contraceptive therapy while on Amitiza. Amitiza is a derivative of a prostaglandin, same one as misoprostol actually. Learn your science, you will then understand why prostaglandins are abortion pills. Okay, get it?

3 - About you not getting the job at Ironwood. Please tell us the feedback you were given from the recruiters, or did you actually make it to a face-to-face with management? I'm really curious the reasons on why they didn't send you on? Could be your business acumen?

4 - Here's a bonus. Since you are the OP of this thread, here's the difference between Ironwood and Takeda. Ironwood will ethically address the boxed warning for peds. Takeda swept under the rug the issue that Amitiza is a derivative of the same prostaglandin that misoprostol is from. Fortunately, there were many Novartis reps in the field that were able to consult the docs about this. Since Linzess is a IBS drug, you will see the patient population that will be targeted are these women of child bearing age (not peds, and remind you those women must take a preg test and be monitored on contraceptive therapy while on Amitiza).
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  #17  
Old 11-19-2012, 01:28 PM
Anonymous
 
Posts: n/a
Default Re: WHY LINZESS KILLS MICE

Quote:
Originally Posted by Anonymous View Post
You are an absolute moron. Let me address your 3 points here.

1 - Zelnorm - was not removed due to CV's with women of child bearing age, this happened in elderly patients. Since you sell Amitiza currently, you would know that 95% of docs felt it was BS that Zelnorm was removed in the way that it was.

2 - Pregnancy Cat C, really? You think this means anything? Nobody is suggesting that we will be targeting actual pregnant women for this drug. Millions of women of child bearing age (that is old enough to be pregnant, but not actually pregnant-in case you don't understand what that means) are currently on SSRI therapy, just one example. Here's the big difference between these SSRI's, Linzess and Amitiza. The label for Amitiza states a woman of child bearing age must have a negative pregnancy test and be monitored on contraceptive therapy while on Amitiza. Amitiza is a derivative of a prostaglandin, same one as misoprostol actually. Learn your science, you will then understand why prostaglandins are abortion pills. Okay, get it?

3 - About you not getting the job at Ironwood. Please tell us the feedback you were given from the recruiters, or did you actually make it to a face-to-face with management? I'm really curious the reasons on why they didn't send you on? Could be your business acumen?

4 - Here's a bonus. Since you are the OP of this thread, here's the difference between Ironwood and Takeda. Ironwood will ethically address the boxed warning for peds. Takeda swept under the rug the issue that Amitiza is a derivative of the same prostaglandin that misoprostol is from. Fortunately, there were many Novartis reps in the field that were able to consult the docs about this. Since Linzess is a IBS drug, you will see the patient population that will be targeted are these women of child bearing age (not peds, and remind you those women must take a preg test and be monitored on contraceptive therapy while on Amitiza).
Ouch

The OP was schooled!
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  #18  
Old 11-19-2012, 08:20 PM
Anonymous
 
Posts: n/a
Party Re: WHY LINZESS KILLS MICE

Quote:
Originally Posted by Anonymous View Post
You are an absolute moron. Let me address your 3 points here.

1 - Zelnorm - was not removed due to CV's with women of child bearing age, this happened in elderly patients. Since you sell Amitiza currently, you would know that 95% of docs felt it was BS that Zelnorm was removed in the way that it was.

2 - Pregnancy Cat C, really? You think this means anything? Nobody is suggesting that we will be targeting actual pregnant women for this drug. Millions of women of child bearing age (that is old enough to be pregnant, but not actually pregnant-in case you don't understand what that means) are currently on SSRI therapy, just one example. Here's the big difference between these SSRI's, Linzess and Amitiza. The label for Amitiza states a woman of child bearing age must have a negative pregnancy test and be monitored on contraceptive therapy while on Amitiza. Amitiza is a derivative of a prostaglandin, same one as misoprostol actually. Learn your science, you will then understand why prostaglandins are abortion pills. Okay, get it?

3 - About you not getting the job at Ironwood. Please tell us the feedback you were given from the recruiters, or did you actually make it to a face-to-face with management? I'm really curious the reasons on why they didn't send you on? Could be your business acumen?

4 - Here's a bonus. Since you are the OP of this thread, here's the difference between Ironwood and Takeda. Ironwood will ethically address the boxed warning for peds. Takeda swept under the rug the issue that Amitiza is a derivative of the same prostaglandin that misoprostol is from. Fortunately, there were many Novartis reps in the field that were able to consult the docs about this. Since Linzess is a IBS drug, you will see the patient population that will be targeted are these women of child bearing age (not peds, and remind you those women must take a preg test and be monitored on contraceptive therapy while on Amitiza).
You've conveniently never answered my question of why there is no electrolyte balance data in your package insert. The answer is because it didn't look good and Ironwood dumped it into the "on file" category. That's why it isn't safe for mice/young people. Your abortion non-sense will make you look like idiots in the near-term future when Amitiza gets approved for children! That's why we don't have a blackbox warning and you do. Don't worry. We'll let the GI's know why you got the blackbox warning.
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  #19  
Old 11-19-2012, 09:02 PM
Anonymous
 
Posts: n/a
Default Re: WHY LINZESS KILLS MICE

Quote:
Originally Posted by Anonymous View Post
You've conveniently never answered my question of why there is no electrolyte balance data in your package insert. The answer is because it didn't look good and Ironwood dumped it into the "on file" category. That's why it isn't safe for mice/young people. Your abortion non-sense will make you look like idiots in the near-term future when Amitiza gets approved for children! That's why we don't have a blackbox warning and you do. Don't worry. We'll let the GI's know why you got the blackbox warning.
You're a genius riding to school on the short bus, data can't be "on file" and not included in PI. The FDA is making up for years of looking the other way and now requiring all clinical trial data be included in PIs. Let the drs know about our black box warning, ped GIs aren't in our target base anyway
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  #20  
Old 11-19-2012, 09:03 PM
Anonymous
 
Posts: n/a
Default Re: WHY LINZESS KILLS MICE

Quote:
Originally Posted by Anonymous View Post
You've conveniently never answered my question of why there is no electrolyte balance data in your package insert. The answer is because it didn't look good and Ironwood dumped it into the "on file" category. That's why it isn't safe for mice/young people. Your abortion non-sense will make you look like idiots in the near-term future when Amitiza gets approved for children! That's why we don't have a blackbox warning and you do. Don't worry. We'll let the GI's know why you got the blackbox warning.
Your non-sense electrolyte argument has made you look like an idiot since 2006. Tell me why Miralax and PEGs have 90% share, while Amitiza struggles for 10% of the market? Why is Miralax preferred with docs to use in peds, since electrolyte balance data is so important to you?
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  #21  
Old 11-19-2012, 10:29 PM
Anonymous
 
Posts: n/a
Default Re: WHY LINZESS KILLS MICE

Quote:
Originally Posted by Anonymous View Post
You've conveniently never answered my question of why there is no electrolyte balance data in your package insert. The answer is because it didn't look good and Ironwood dumped it into the "on file" category. That's why it isn't safe for mice/young people. Your abortion non-sense will make you look like idiots in the near-term future when Amitiza gets approved for children! That's why we don't have a blackbox warning and you do. Don't worry. We'll let the GI's know why you got the blackbox warning.
I'm sure your peds indication for Amitiza will work out as well the Dexilant/Plavix message, or the Edarbyclor superiority data..LOL Typical Takeda jack-ass thinking, you guys have no idea on how to sell clinical and end up niching a small part of a market with a "safety" message.
Amitiza no electrolyte imbalance, okay that's great but the drug gives everyone nausea and barely works for an IBS patient. Why do all these "safety" patients and docs prefer Miralax? Not sold on the message!
Rozerem, your patients won't have to worry about slipping and falling in the middle of the night; no balance issues plus it's not addictive. Probably don't need to explain this one...or what about those COPD patients..LOL
Dexilant and Plavix; the latest and greatest hail mary of niching opportunities for Takeda. Docs don't care, they just write Nexium and Plavix and dose them 12 hours apart. GI's have been doing this for years.
Uloric; let's study it against 1/2 the allopurinol dose and then niche it for patients with renal impairment. Wow, another brilliant safety message from Takeda that didn't work.
Get me point? Keep drinking your Takeda cool-aid the way you are, Linzess will crush Amitiza sooner than anyone would have thought. I love the Takeda people. They sure know how to pound non-clinical messages down docs throats that noone cares about! Doesn't your company have about 10,000 bladder cancer lawsuits they need to worry about? I think the TZD class was where Takeda should have tried a "safety" message...LOL
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  #22  
Old 11-19-2012, 10:44 PM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

In the May 2009 edition of the "American Journal of Physiology," suggests that Amitiza also activates chloride channels in other parts of the body, including the tissues that line the lung and respiratory systems. Since widespread chloride channel activation could theoretically lead to imbalances in serum electrolytes, the FDA required the manufacturer of Amitiza, Sucampo Pharmaceuticals, to specifically test serum electrolytes during clinical trials.

Kind of interesting, the company with the drug that touts "no electrolyte imbalances" was forced by the FDA to specifically test serum electrolytes during clinical trials. If this was so important, why didn't Sucampo/Takeda do this voluntarily rather via FDA mandate?
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  #23  
Old 11-20-2012, 09:22 AM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

Quote:
Originally Posted by Anonymous View Post
I'm sure your peds indication for Amitiza will work out as well the Dexilant/Plavix message, or the Edarbyclor superiority data..LOL Typical Takeda jack-ass thinking, you guys have no idea on how to sell clinical and end up niching a small part of a market with a "safety" message.
Amitiza no electrolyte imbalance, okay that's great but the drug gives everyone nausea and barely works for an IBS patient. Why do all these "safety" patients and docs prefer Miralax? Not sold on the message!
Rozerem, your patients won't have to worry about slipping and falling in the middle of the night; no balance issues plus it's not addictive. Probably don't need to explain this one...or what about those COPD patients..LOL
Dexilant and Plavix; the latest and greatest hail mary of niching opportunities for Takeda. Docs don't care, they just write Nexium and Plavix and dose them 12 hours apart. GI's have been doing this for years.
Uloric; let's study it against 1/2 the allopurinol dose and then niche it for patients with renal impairment. Wow, another brilliant safety message from Takeda that didn't work.
Get me point? Keep drinking your Takeda cool-aid the way you are, Linzess will crush Amitiza sooner than anyone would have thought. I love the Takeda people. They sure know how to pound non-clinical messages down docs throats that noone cares about! Doesn't your company have about 10,000 bladder cancer lawsuits they need to worry about? I think the TZD class was where Takeda should have tried a "safety" message...LOL
I work for Takeda and was going to talk some shit. But this is too true and too funny!
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  #24  
Old 11-20-2012, 07:57 PM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

So what kind of managed care coverage will Linzess have at launch? And what about by the end of 1st quarter 2013?
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  #25  
Old 11-20-2012, 08:30 PM
Anonymous
 
Posts: n/a
Default Re: WHY LINZESS KILLS MICE

Quote:
Originally Posted by Anonymous View Post
I work for a REAL GI company, selling UC and Crohns meds. Unlike you, I'm actually a specialty rep and do not call on PCP's. I had a lot of former colleagues come work here, that is why I "troll" this site, as you put it. Just think it is really funny everyone jumped ship to sell a baby killing product.
A Shire rep that may not have a job in 2 weeks, now thats funny! You also don't sell Crohn's meds, or did you forget about that nasty little FDA letter already? Don't worry, the FDA will remind you shortly with a nice fine. You should have joined your more successful colleagues and left when you had the chance. You have zero pipeline and a 18 yr old drug. Good luck pal.
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  #26  
Old 11-20-2012, 10:02 PM
Anonymous
 
Posts: n/a
Default Re: WHY LINZESS KILLS MICE

Quote:
Originally Posted by Anonymous View Post
I work for a REAL GI company, selling UC and Crohns meds. Unlike you, I'm actually a specialty rep and do not call on PCP's. I had a lot of former colleagues come work here, that is why I "troll" this site, as you put it. Just think it is really funny everyone jumped ship to sell a baby killing product.
Yup a "specialty" rep who gets paid like a PCP rep. Good luck with the re-alignment, keep drinking the Shire Kool-Aid, I'm sure that the GIBU can add more head-count.

Lialda is in a decline stage after just 5 years, Resolor is DOA, sounds like your future is bright.
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  #27  
Old 04-15-2013, 07:00 AM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

Not sure if anyone is still monitoring this thread, but as someone who is using linzess, I thought I'd throw in my two cents. I don't work for a pharm company, and judging by the cattiness between those posting here not sure I'd want to, but as someone who suffers from IBS C, linzess has been a lifesaver. No other drug (OTC or prescription), and no natural "cures" (fiber, magnesium, castor oil) have worked for me. Granted, while young, I have already gone through menopause, so pregnancy isn't an issue for me, but even with possible side effects, this drug has been a god send for me. Just wanted to put that out there. Lucky for me, I'm not a mouse.
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  #28  
Old 04-15-2013, 10:16 AM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

Quote:
Originally Posted by Anonymous View Post
Not sure if anyone is still monitoring this thread, but as someone who is using linzess, I thought I'd throw in my two cents. I don't work for a pharm company, and judging by the cattiness between those posting here not sure I'd want to, but as someone who suffers from IBS C, linzess has been a lifesaver. No other drug (OTC or prescription), and no natural "cures" (fiber, magnesium, castor oil) have worked for me. Granted, while young, I have already gone through menopause, so pregnancy isn't an issue for me, but even with possible side effects, this drug has been a god send for me. Just wanted to put that out there. Lucky for me, I'm not a mouse.
The cattiness comes from reps at Takeda that sell the competition, Amitiza. Most of them interviewed to sell Linzess and didn't get the job. Glad Linzess works for you. This site drags in many disgruntled reps, that should also explain the silliness you read here.
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  #29  
Old 07-27-2014, 05:47 PM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

My daughter is pregnant and her ob gave her the ok to continue linzess???
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  #30  
Old 07-28-2014, 01:56 PM
Anonymous
 
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Default Re: WHY LINZESS KILLS MICE

This is a joke, if you are soliciting medical advice on a message board you have problems
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