Amedica's Si3n4 great fit for Nuvasive

Boston745 · Jan 7, 2018 at 11:53 AM

Has anyone looked at this tech and seen all the great things that could take nuvasive leaps ahead of Medtronic? Nothing like this material and it will be the future of spine.

anonymous · Jan 9, 2018 at 10:11 AM

^^^^Boston 745- your a clown. You have been trying to drum up interest in this garbage company on the Zimmer board for months, and even made an attempt on the Stryker board. I though it was a done deal that Zimmer was going to buy>>>you even gave a date. Your blog is garbage, just face the fact that your stock in worthless, even if they do get bought. It has been reversed split so much to avoid being a penny stock and delisted. I just want bankruptcy and I will claim as a loss on my taxes.

anonymous · Jan 9, 2018 at 8:42 PM

anonymous said: ↑

^^^^Boston 745- your a clown. You have been trying to drum up interest in this garbage company on the Zimmer board for months, and even made an attempt on the Stryker board. I though it was a done deal that Zimmer was going to buy>>>you even gave a date. Your blog is garbage, just face the fact that your stock in worthless, even if they do get bought. It has been reversed split so much to avoid being a penny stock and delisted. I just want bankruptcy and I will claim as a loss on my taxes.
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Still chasing after me trying to squash everything proves you are a paid shill. What you gonna do, post all this to stock twits and ihub? Nothing happens, more clocks then ever on my blog. That's what spot on research does.

anonymous · Jan 9, 2018 at 8:43 PM

anonymous said: ↑

Still chasing after me trying to squash everything proves you are a paid shill. What you gonna do, post all this to stock twits and ihub? Nothing happens, more clocks then ever on my blog. That's what spot on research does.
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*clicks. Sorry CP spelling police. Caught it quick.

anonymous · Jan 17, 2018 at 9:35 AM

Only people who think Amedica is great are for people from Amedica. Company needs to spend millions on independent studies not linked to anyone that works at Amedica. White papers are meaningless to the rest of the world when they are compromised and Amedica won't even aknowledge it. Everyone who doesn't have money invested in this company can see it clear as day. Those who choose to put skin in the game have tunnel vision. Look at Amedicas numbers. Maybe 150 people believe in the tech? There are milllions in this industry world wide that see through the fluff and want some real studies done. Amedica refuses which makes us all wonder why? So no, I don't see this as a fit for us, and I don't see Amedica keeping the doors open without some serious overhauling. Start with that CEO/CFO/President. A Dr that runs the show? It's no wonder the business is not being run as a device company should be. Get business minded leaders and save the doctors for the shows.

anonymous · Mar 7, 2018 at 7:55 PM

Nuvasive already bought porous peek. They are talking about zimmer is about to own si3n4 to profit soon.

http://www.cafepharma.com/boards/threads/amedica-and-zimmer-soon-to-be-one.612417/page-4

anonymous · May 23, 2018 at 3:39 PM

Amedica has to pay Mekong Capital, a Vietnamese Bank over $1 million by February.

Don't think Nuva is gonna jump on Amedica with its toxic debt. A ceramic implant is out of Nuva's ballfield

anonymous · May 23, 2018 at 3:48 PM

In 2017 Amedica reported $15.23 million in revenue, a $14.76 milion net loss in revenue from the prior year.

Not exactly a fish you wish to catch.

The Dr. ran show also has a lawyer background .....also something that puts a sour taste in your mouth.

The good Doctor was disqualified from being a Professional Witness in Federal Court cases....something he SHOULD HAVE KNOWN....that also is a blemish on the record.

anonymous · May 23, 2018 at 3:55 PM

Boston745 is Dr. Bal of Amedica it appears

https://investorshub.advfn.com/boards/profilea.aspx?user=535857

anonymous · May 23, 2018 at 3:56 PM

Go to google and search for 'boston745'

Appears to be the Big Boss of Amedica himself

anonymous · May 23, 2018 at 4:06 PM

"Zimmer Mobi + Si3N4 = new class of Artificials Discs" , from your Stocktwits post....

If Zimmer bought Amedica to make such a disc...it wont sell.

Your posts that Titanium implants corrode and lead to heavy metals in the blood...to justify Si3N4..

If it had ANY truth to it you would OWN the entire surgical implant field and become a Billion dollar company over night.

anonymous · Oct 20, 2018 at 2:05 AM

anonymous said: ↑

"Zimmer Mobi + Si3N4 = new class of Artificials Discs" , from your Stocktwits post....

If Zimmer bought Amedica to make such a disc...it wont sell.

Your posts that Titanium implants corrode and lead to heavy metals in the blood...to justify Si3N4..

If it had ANY truth to it you would OWN the entire surgical implant field and become a Billion dollar company over night.
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Other Increased Metal Levels in Patients with Revision Surgeries
The 11 patients who required revision surgeries following corrosion of hip replacement devices also experienced a surge in other levels of metal in the bloodstream. The research study indicates that one 65-year old male patient had a level of titanium in his bloodstream of 5.8, and this deviated more than two points from the standard mean. Another 66-year old female patient showed a presence of titanium that was 4.9, which was also significantly over the standard mean of 3.4.
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anonymous · Oct 20, 2018 at 2:16 AM

TITANIUM
Titanium is a high-strength, highly corrosion resistant, low allergic potential metal commonly used in stainless steels
as a stabilising element. Pure titanium and the alloy titanium-aluminium-vanadium (Ti–6Al–4V) are among the most
widely used for biomedical applications42. Although regarded as a relatively inert metal, accumulation of titanium
particles and ions can induce osteolytic cytokines and inhibit osteoblast collagen expression in vitro. Raised serum
levels of titanium have been found within synovial uid, serum and urine of patients after total hip and knee
arthroplasty and following instrumented spinal arthrodesis
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https://www.researchgate.net/publication/279995715_Modern_Metal_Implant_Toxicity_and_Anaesthesia

anonymous · Oct 20, 2018 at 2:19 AM

Evidence for corrosion and wear of spine implants in current clinical practice

Several case reports have been published on revision of spine components where the reason for revisions were strongly linked with corrosion and wear of the implants [1–7]. Medical complications included unexplained pain, neurological effects, implant loosening, implant failure, swelling and metal staining of the skin.
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https://orthostreams.com/2016/12/paper-a-review-of-corrosion-of-spine-implants/

anonymous · Oct 20, 2018 at 10:56 AM

They found that control individuals had very low levels of titanium in the blood whereas titanium concentrations were significantly higher for all the patients with implants. The sensitivity of the method was such that the researchers were also able to show significant differences in titanium levels for different types of bone fixation devices. The more invasive implants shed more metallic debris into the blood than the external, superficial designs. The work also identified how the titanium from the implants is transported in the bloodstream and potentially distributed and accumulated.
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https://www.sciencedaily.com/releases/2011/07/110725101257.htm

anonymous · Oct 20, 2018 at 3:10 PM

Meanwhile Si3N4 dissolves in an aqueous enviornment at faster pace than expected wear debris. Sounds biodegradable to me.

Wear debris generated from SiNx coatings was round in shape, with a mean size of 40 nm, and ranged between 10 and 500 nm. Model particles, similar in size and shape as the wear debris, were soluble in simulated body fluid. The dissolution rate was higher than the expected rate of debris generation. Along with the size of the debris, which is not in the critical range for macrophage activation, this dissolution may limit negative biological reactions. The SiNx coatings also dissolved in simulated body fluid. The coating with the highest N/Si ratio exhibited the lowest dissolution rate, of 0.2 to 0.4 nm/ day, while CoCrMo under the same condition dissolved at a rate of 0.7 to 1.2 nm/day. SiNxcoated CoCrMo exhibited a reduced release of Co, Cr and Mo ions into the solution by two orders of magnitude, compared to uncoated CoCrMo. Si3N4 evaluated under micro-displacement in a corrosive environment, replicating the modular taper, showed a lower corrosion current compared to common biomedical alloys. SiNx coatings may also act beneficially to reduce issues associated with this type of contact. SiNx coatings have shown several properties in a laboratory environment that are hypothesised to increase the longevity of joint replacements. The promising results encourage further evaluation closer to the clinical application of total hip replacements, in particular in the articulating bearing surface and in modular tapers.
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anonymous · Nov 4, 2018 at 6:34 PM

Titanium has the ability to interact with the essential mineral silica, therefore signs and or symptoms of silica deficiency can be an indication of a titanium excess.

Silica deficiency – soft or brittle nails, premature wrinkles, thinning or loss of hair,poor bone development and osteoporosis can all be indications of titanium toxicity.
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Titanium interferes with bodies ability to utilize Silicia an essential mineral for bone development. Si3N4 breaks down into silica which the body can then use to grow/strengthen bones.

anonymous · Nov 6, 2018 at 5:44 PM

RESULTS: Thirty-two patients were included in the study group. Mean age at surgery was 14.7 years. Preoperative and postoperative concentrations of serum titanium and niobium were significantly different (P = 0.0001). Median postoperative serum concentrations of titanium and niobium were elevated 2.4- and 5.9-fold above the normal range respectively with 95% and 99% of samples elevated postoperatively. A significant and rapid rise in serum titanium and niobium levels was observed within the first postoperative week, after which elevated serum levels persisted up to 12 months.

CONCLUSION: We report abnormally elevated serum titanium and niobium levels in patients with titanium-based spinal instrumentation up to 12 months. The long-term systemic consequences of debris generated by wear and corrosion of spinal instrumentation is unclear but concerning, particularly as these implants inserted into the pediatric population may remain in situ for beyond 6 decades.
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https://www.sciencedirect.com/science/article/pii/S1549963418300108

anonymous · Dec 11, 2018 at 5:34 PM

New Rochelle, NY, Sept. 14, 2017 -- Researchers from the Mayo Clinic have proposed that negative cellular responses to titanium-based nanoparticles released from metal implants interfere in bone formation and resorption at the site of repair, resulting in implant loosening and joint pain. Their review of recent scientific evidence and call for further research to characterize the biological, physical, and chemical interactions between titanium dioxide nanoparticles and bone-forming cells
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https://www.eurekalert.org/pub_releases/2017-09/mali-dtd091417.php

anonymous · Dec 11, 2018 at 6:01 PM

High doses of nano-TiO2significantly damaged the functions of liver and kidney and glucose and lipid metabolism, as showed in the blood biochemistry tests. Nano-TiO2caused damages in mitochondria and apoptosis of hepatocytes, generation of reactive oxygen species, and expression disorders of protective genes in the liver of mice. We found ruptured and cracked nerve cells and inflammatory cell infiltration in the brain. We also found that the activities of constitutive nitric oxide synthases (cNOS), inducible NOS (iNOS), and acetylcholinesterase, and the levels of nitrous oxide and glutamic acid were changed in the brain after nano-TiO2 exposure. Ex vivo mouse embryo models exhibited developmental and genetic toxicity after high doses of nano-TiO2.
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https://nanoscalereslett.springeropen.com/articles/10.1186/s11671-017-2242-2

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