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<p>[QUOTE="not so concerned scientist, post: 3005287"]Concerned Scientist,</p><p><br /></p><p>I believe your thought process is partially correct! The difference between Osteocel and Osteocel plus is the validation! However, is th evalidation even relavant! Through the process of Selective Immunodepletion the "other cells" RBC, White Cells, etc.. are removed! This in theory leaves the STEm Cells! From different sources I have spoken with the cell count after the process is far greater than 250,000 MSC! Probbaly closer to 700,00 depending upon many factors..age, health, lifesyle, etc.. The question is how pure are these cells! MCS's can be further subdivided in 4 catergories as you noted! Bone, Tissue, Cartilage, Adipose tissue, and in addition Cardiac tissue! </p><p><br /></p><p>The transitory process of growing bone goes thru the cartilage linage phase! In otherwords to grow bone you must go thru the tissue-cartilage-bone phase! The signal of the bon ein the body being the highest! Therefore it is easy to make MSC flip to a progenitor cell when put around a host (bone) with a high signal! What causes th eprogenitor cell to decide to be on or the other is the amount of surrounding Growth factors present to get it to make it's decision. Bone having the highest signal! The real science is figuring out how to further immunodeplete The MSC into bone, CArtilage, Adipose cells! Truly then can you claim pure cell viablity!</p><p><br /></p><p>All of the products use cancellous bone as a host or carrier for the MSC's to bind! The signal of the product is minimal due to the fact that the MSC can turn directly into a Progenitor cell and then into transitory osteoblast usin gthe bodies own signalling of growth factors to come in via platlets and lay down growth factors!!! </p><p><br /></p><p>Basically, all of these products are th esame with a great "new" marketing spin put on Osteocel PLUS! </p><p><br /></p><p>To the previous poster in reference to MTF vs Osiris! That is not the issue! Allosource is a far superior tissue bank to MTF and this can be found in the simple fact that they have a validated process to Sterilize tissue and they only get donors from 5 OPO's. Plus they process in class 5 clean rooms!</p><p><br /></p><p>Also, i'm curious how MTF will spin their Cryopreserven, Unpurged, Cancellous as a Stem Cell product that doesn't have Allogenic response!! Good luck with that one!![/QUOTE]</p><p><br /></p>
[QUOTE="not so concerned scientist, post: 3005287"]Concerned Scientist, I believe your thought process is partially correct! The difference between Osteocel and Osteocel plus is the validation! However, is th evalidation even relavant! Through the process of Selective Immunodepletion the "other cells" RBC, White Cells, etc.. are removed! This in theory leaves the STEm Cells! From different sources I have spoken with the cell count after the process is far greater than 250,000 MSC! Probbaly closer to 700,00 depending upon many factors..age, health, lifesyle, etc.. The question is how pure are these cells! MCS's can be further subdivided in 4 catergories as you noted! Bone, Tissue, Cartilage, Adipose tissue, and in addition Cardiac tissue! The transitory process of growing bone goes thru the cartilage linage phase! In otherwords to grow bone you must go thru the tissue-cartilage-bone phase! The signal of the bon ein the body being the highest! Therefore it is easy to make MSC flip to a progenitor cell when put around a host (bone) with a high signal! What causes th eprogenitor cell to decide to be on or the other is the amount of surrounding Growth factors present to get it to make it's decision. Bone having the highest signal! The real science is figuring out how to further immunodeplete The MSC into bone, CArtilage, Adipose cells! Truly then can you claim pure cell viablity! All of the products use cancellous bone as a host or carrier for the MSC's to bind! The signal of the product is minimal due to the fact that the MSC can turn directly into a Progenitor cell and then into transitory osteoblast usin gthe bodies own signalling of growth factors to come in via platlets and lay down growth factors!!! Basically, all of these products are th esame with a great "new" marketing spin put on Osteocel PLUS! To the previous poster in reference to MTF vs Osiris! That is not the issue! Allosource is a far superior tissue bank to MTF and this can be found in the simple fact that they have a validated process to Sterilize tissue and they only get donors from 5 OPO's. Plus they process in class 5 clean rooms! Also, i'm curious how MTF will spin their Cryopreserven, Unpurged, Cancellous as a Stem Cell product that doesn't have Allogenic response!! Good luck with that one!![/QUOTE]
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Cafepharma Message Boards | Pharma Sales, Device Sales, Lab Sales
Home
Forums
>
Medical Equipment/Device Sales
>
NuVasive
>
NuVasive to carry Osteocel
>
Cafepharma Message Boards | Pharma Sales, Device Sales, Lab Sales
Home
Forums
>
Medical Equipment/Device Sales
>
NuVasive
>
NuVasive to carry Osteocel
>