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<p>[QUOTE="Anonymous, post: 5201767"]Actually, euphoria is a consequence of a spike in plasma concentration commonly associated with immediate release opioid formulations. With some extended release products, euphoria can be mitigated because the PK profile is altered. I agree with you where patients will feel euphoric sensations if the dose is too high, especially when converting to a different molecule. However starting low and going slow is too conservative of an approach where the physician runs the risk of lack of analgesia which can be a severe consequence in chronic pain patients. The best case scenario is getting the conversion and titration as close as possible to the correct ratio.[/QUOTE]</p><p><br /></p>
[QUOTE="Anonymous, post: 5201767"]Actually, euphoria is a consequence of a spike in plasma concentration commonly associated with immediate release opioid formulations. With some extended release products, euphoria can be mitigated because the PK profile is altered. I agree with you where patients will feel euphoric sensations if the dose is too high, especially when converting to a different molecule. However starting low and going slow is too conservative of an approach where the physician runs the risk of lack of analgesia which can be a severe consequence in chronic pain patients. The best case scenario is getting the conversion and titration as close as possible to the correct ratio.[/QUOTE]
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Cafepharma Message Boards | Pharma Sales, Device Sales, Lab Sales
Home
Forums
>
Pharma/Biotech Companies
>
Zogenix
>
Sell some Zohydro!!
>
Cafepharma Message Boards | Pharma Sales, Device Sales, Lab Sales
Home
Forums
>
Pharma/Biotech Companies
>
Zogenix
>
Sell some Zohydro!!
>