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WHY LINZESS KILLS MICE

Discussion in 'Ironwood Pharmaceuticals' started by Anonymous, Nov 17, 2012 at 8:15 AM.

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  1. Anonymous

    Anonymous Guest

    Just met with a GI today who saw your booth at the ACG in Las Vegas. He asked, "The Linzess booth didn't have much information. What do you think about your newest competitor?" He was surprised to learn that it has a black box warning and asked why. I told him, "It's because Linzess causes a significant electrolyte imbalance and kills young mice. Just imagine if a patient's children or grand children got ahold of it and ate it. Would you want to take that chance?" He responded that he couldn't believe the FDA would approve a drug that dangerous. Good luck selling the rat poison!
     
  2. Anonymous

    Anonymous Guest

    Imagine if your wife was unknowingly pregnant, you know the first month or two before most women find out. She then took her Amitiza and your unborn child died as a result of her taking the prostaglandin abortion pill for her IBS. It's a crazy world out there, makes you wonder how many other unborn children died as a result of taking their Amitiza when the mother didn't know she was pregnant.
     
  3. Anonymous

    Anonymous Guest

    Hey baby killer, I also forgot to say..

    I'm sorry you didn't get the job
     
  4. Anonymous

    Anonymous Guest

    Uhh, Linzess is pregnancy category C as well.
     
  5. Anonymous

    Anonymous Guest

    Read your PI amitiza tool boy. Linzess does not cause abortions, nor is a pregnancy test required prior to starting therapy.
     
  6. Anonymous

    Anonymous Guest

    If you plan to convince doctors that your Pregnancy Category C drug is safer for women than other Pregnancy Category C drugs- Good luck with that!
     
  7. Anonymous

    Anonymous Guest

    Again, read your own PI jackass. Amitiza does indeed kill unborn children in guinea pigs!
     
  8. Anonymous

    Anonymous Guest

    I'm really sorry you didn't get the job. Forest has some open positions and they have many contract sales teams that work with them. Perhaps you should try to work at one of those companies since Ironwood didn't work out for you.
     
  9. Anonymous

    Anonymous Guest

    The abortifacient activity of lubiprostone is evident in the data from the pregnant guinea pig study. A preliminary range-finding study showed that abortions occurred in 4% of pregnant females at a dose of 5 micrograms per kilogram (µg/kg). That study was followed by a second, larger study showing dose-dependent abortions beginning at 1 µg/kg. Abortions occurred in 0%, 3.8%, 8.0%, and 19% (0, 1, 10, 25 µg/kg) (see Figure 1). There were 22 to 26 pregnant guinea pigs for each dose. The 1 µg/kg dose in guinea pigs is approximately the same exposure as the 48 µg dose in women.
     
  10. Anonymous

    Anonymous Guest

    C=Linzess=Amitiza= Same safety for women. If you can't make that conclusion then it explains why Takeda fired you during the last layoff and why you had to take the Ironwood job. Good luck selling with a black box warning!
     
  11. Anonymous

    Anonymous Guest

    Dude, chill with the not getting the job thing. When the recruiter emailed me the drug, I didn't even respond. I'm glad you found a job though, especially since you'll be talking cc and ibs-c, only creating more awareness. But seriously, even if you run the table and put amitiza in the ground, plecanatide is going to bend you over hard. How's your pipeline?
     
  12. Anonymous

    Anonymous Guest

    Says the troll that is always posting on a companies site he doesn't work for...LOL
     
  13. Anonymous

    Anonymous Guest


    Data from animal reproduction studies performed by Sucampo Pharmaceuticals and submitted to the FDA indicate that pregnant guinea pigs treated with Amitiza at doses two to six times higher than the highest recommended human doses between days 40 and 53 of gestation experienced fetal loss, also known as miscarriage.
     
  14. Anonymous

    Anonymous Guest

    I work for a REAL GI company, selling UC and Crohns meds. Unlike you, I'm actually a specialty rep and do not call on PCP's. I had a lot of former colleagues come work here, that is why I "troll" this site, as you put it. Just think it is really funny everyone jumped ship to sell a baby killing product.
     
  15. Anonymous

    Anonymous Guest

    Stop with I know you did not get the job.

    The fact that these drugs are preg C , so what many drugs are.

    The problem will be safer OTC drugs remember Zelnorm.