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<p>[QUOTE="Anonymous, post: 4563254"]The abortifacient activity of lubiprostone is evident in the data from the pregnant guinea pig study. A preliminary range-finding study showed that abortions occurred in 4% of pregnant females at a dose of 5 micrograms per kilogram (µg/kg). That study was followed by a second, larger study showing dose-dependent abortions beginning at 1 µg/kg. Abortions occurred in 0%, 3.8%, 8.0%, and 19% (0, 1, 10, 25 µg/kg) (see Figure 1). There were 22 to 26 pregnant guinea pigs for each dose. The 1 µg/kg dose in guinea pigs is approximately the same exposure as the 48 µg dose in women.[/QUOTE]</p><p><br /></p>
[QUOTE="Anonymous, post: 4563254"]The abortifacient activity of lubiprostone is evident in the data from the pregnant guinea pig study. A preliminary range-finding study showed that abortions occurred in 4% of pregnant females at a dose of 5 micrograms per kilogram (µg/kg). That study was followed by a second, larger study showing dose-dependent abortions beginning at 1 µg/kg. Abortions occurred in 0%, 3.8%, 8.0%, and 19% (0, 1, 10, 25 µg/kg) (see Figure 1). There were 22 to 26 pregnant guinea pigs for each dose. The 1 µg/kg dose in guinea pigs is approximately the same exposure as the 48 µg dose in women.[/QUOTE]
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Cafepharma Message Boards | Pharma Sales, Device Sales, Lab Sales
Home
Forums
>
Pharma/Biotech Companies
>
Ironwood Pharmaceuticals
>
WHY LINZESS KILLS MICE
>
Cafepharma Message Boards | Pharma Sales, Device Sales, Lab Sales
Home
Forums
>
Pharma/Biotech Companies
>
Ironwood Pharmaceuticals
>
WHY LINZESS KILLS MICE
>