Who will be the biggest pharma players in orphan drugs?

Who will be the biggest pharma players in orphan drugs?

Source: 
Pharmaforum
snippet: 

New analysis from GlobalData has identified the predicted top 15 pharma players in 2025 for organ drugs, with Roche coming out in the lead.

The research also notes that M&A deals have been the primary way in which big pharma companies secure these orphan drug designations, with very few rare disease drugs being developed in-house.