Hey I work in a surgery center and we can't find our recipe/mixing instructions for diluting tisseel for ptygerium and plastic surgery cases. Our Baxter rep gave us instructions on how to dilute it but we cannot find it. Please help.
Your compliance lawyers need to pull their heads out of their asses and rein in your ridiculous off label tactics. Then again, old habits die hard, especially when the sales quotas increase so much every year.
I just listen to our leaders and sell, sell, sell! Dilution rules!!! Coseal for anti-adhesion, Tisseel for Bariatric, thoracic, colon rectal, dural tears and neurosurgery. Hey we are the only ones that have two indications; sealing and hemostasis (wink, wink). Sell reconstitution(wink, wink)! Pre-sell the full body indication for Tisseel before we get FDA approval (wink, wink)! That's what management is telling everyone to do! While you are at it....Lap sprayers cause it is safe. We make 13 tips for colostomy reversal??? Hey lets bring in Urologist and General surgeons to evaluate Tachosil then we can sell it off label! What a crock! Baxter will never get the indications cause it is cheaper to sell off label.
The dilution formula was sold for years until we came out with Artiss. The dilution formula was not an approved product. We just made up our own slow set until it was approved.
I know Artiss is now available but it is so expensive and comes with a spray set. I do not need a spray set for doing eyes. My rep told me diluted Tisseel was the same thing as Artiss but was cheaper cause of the manual mixing. I think Baxter is trying to take advantage of the surgery center. Just my opinion.
here is what we use: Tisseel VH Fibrin Sealant 2 ml Kit Dilutions for 3 minute cure time (pterygium) 1. Plug in warmer and begin at the start of the operation 2. Use syringe with Blue numbers to mix the Blue vials. a. Mix little blue vial in to big blue vial, place the big blue vial in the Tisseel warmer b. Press the stir button on 3. Use syringe with Black numbers to draw up 1.0 ml of preservative free saline 4. Inject preservative free saline into Thrombin vial, rotate vial until dissolved completely 5. Draw up all of the dissolved Thrombin with the syringe used in step 4, save the empty Thrombin vial 6. Discard 0.9 ml of the dissolved Thrombin, leave 0.1 ml in the syringe 7. Draw up 0.9 ml of preservative free saline to make a total of 1 ml. 8. Repeat step 6: Discard 0.9 ml of dissolved Thrombin, leave 0.1 ml in syringe 9. Draw up 0.4 ml of the preservative free saline to make a total of 0.5 ml. 10. Calcium chloride vial: use the syringe in step 9 to draw up the 0.5 ml of the Calcium chloride for a total of 1 ml. 11. Thrombin vial: inject the 1 ml of solution from step 10 into the Thrombin vial. Discard the syringe. Label Thrombin vial as “Thrombin 5IU/ml”. 12. Continue as per Easy Prep or standard transfer instructions Tisseel: Good for 4 hours after reconstitution. Tisseel VH Fibrin Sealant 2 ml Kit Dilutions for 1 minute cure time (plastics) 1. Plug in warmer and begin at the start of the operation 2. Use syringe with Blue numbers to mix the Blue vials. a. Mix little blue vial in to big blue vial, place the big blue vial in the Tisseel warmer b. Press the stir button on 3. Use syringe with Black numbers to draw up 1.0 ml of preservative free saline 4. Inject preservative free saline into Thrombin vial, rotate vial until dissolved completely 5. Draw up all of the dissolved Thrombin with the syringe used in step 4, save the empty Thrombin vial 6. Discard 0.9 ml of the dissolved Thrombin, leave 0.1 ml in the syringe 7. Draw up 0.4 ml of preservative free saline to make a total of 0.5 ml. 8. Calcium chloride vial: use the syringe in step 7 to draw up the 0.5 ml of the Calcium chloride for a total of 1 ml. 9. Thrombin vial: inject the 1 ml of solution from step 8 into the Thrombin vial. Discard the syringe. Label Thrombin vial as “Thrombin 5IU/ml”. 10. Continue per Easy Prep or standard transfer instructions. Tisseel: Good for 4 hours after reconstitution. Do not use iodine or heavy metal containing preparations such as betadine for disinfection of vial stoppers. Allow alcohol-based disinfectants to evaporate before puncturing stopper.
Nice job Butch. Now get back to the happy hour… QUOTE="Anonymous, post: 4336989"]here is what we use: Tisseel VH Fibrin Sealant 2 ml Kit Dilutions for 3 minute cure time (pterygium) 1. Plug in warmer and begin at the start of the operation 2. Use syringe with Blue numbers to mix the Blue vials. a. Mix little blue vial in to big blue vial, place the big blue vial in the Tisseel warmer b. Press the stir button on 3. Use syringe with Black numbers to draw up 1.0 ml of preservative free saline 4. Inject preservative free saline into Thrombin vial, rotate vial until dissolved completely 5. Draw up all of the dissolved Thrombin with the syringe used in step 4, save the empty Thrombin vial 6. Discard 0.9 ml of the dissolved Thrombin, leave 0.1 ml in the syringe 7. Draw up 0.9 ml of preservative free saline to make a total of 1 ml. 8. Repeat step 6: Discard 0.9 ml of dissolved Thrombin, leave 0.1 ml in syringe 9. Draw up 0.4 ml of the preservative free saline to make a total of 0.5 ml. 10. Calcium chloride vial: use the syringe in step 9 to draw up the 0.5 ml of the Calcium chloride for a total of 1 ml. 11. Thrombin vial: inject the 1 ml of solution from step 10 into the Thrombin vial. Discard the syringe. Label Thrombin vial as “Thrombin 5IU/ml”. 12. Continue as per Easy Prep or standard transfer instructions Tisseel: Good for 4 hours after reconstitution. Tisseel VH Fibrin Sealant 2 ml Kit Dilutions for 1 minute cure time (plastics) 1. Plug in warmer and begin at the start of the operation 2. Use syringe with Blue numbers to mix the Blue vials. a. Mix little blue vial in to big blue vial, place the big blue vial in the Tisseel warmer b. Press the stir button on 3. Use syringe with Black numbers to draw up 1.0 ml of preservative free saline 4. Inject preservative free saline into Thrombin vial, rotate vial until dissolved completely 5. Draw up all of the dissolved Thrombin with the syringe used in step 4, save the empty Thrombin vial 6. Discard 0.9 ml of the dissolved Thrombin, leave 0.1 ml in the syringe 7. Draw up 0.4 ml of preservative free saline to make a total of 0.5 ml. 8. Calcium chloride vial: use the syringe in step 7 to draw up the 0.5 ml of the Calcium chloride for a total of 1 ml. 9. Thrombin vial: inject the 1 ml of solution from step 8 into the Thrombin vial. Discard the syringe. Label Thrombin vial as “Thrombin 5IU/ml”. 10. Continue per Easy Prep or standard transfer instructions. Tisseel: Good for 4 hours after reconstitution. Do not use iodine or heavy metal containing preparations such as betadine for disinfection of vial stoppers. Allow alcohol-based disinfectants to evaporate before puncturing stopper.[/QUOTE]
