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Here are it's reasons. 

• Having to commit to borderline harassment of the doctors without a product entire 1st qtr. Some likely to get EPOs against our sales force.
• BIs largely denied/mishandled irritating office staff
• 12 weeks of same marketing material - PI  "Hi doctor, I'm here to speak to you at week 10 about the PI that we covered for the last 9 weeks." 
• Low grade stress of middle management pushed onto CLs
• "It'll be OK" mid afternoon conference calls.
• Webinars for docs at bedtime
• No knowledge of where Sublocade will be covered or not for entire first quarter
• Management is oozing panic, lashing out at their teams

Now it's your turn to present another company or product that you feel can top that.  Godspeed.