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I am on Provigil for Fibromyalgia? Chronic Fatigue Etc you name it I got it! However after almost 4 months on Provigil.  I am Moody to excess, suffering severe bouts of depression and anxiety, cry at the drop of a hat, am having uncontrollable twitching and jerking of my muscles, difficulty breathing right, grinding my teeth causing my TMJ to flare up horribly, can't sleep for more then 2-3 hrs at a time, feel in general just awful but even more awful when I try to quit taking it. So I have decided until I can reach my Dr. I am going to taper myself off of this horrid drug!

Every medicine affects every person in a different way I seem to be extremely sensitive to any drugs that affect brain receptors/chemistry etc. as the SSRI's and other Psych Meds that the Dr's push on us who suffer from chronic physical pain because they are so afraid to just keep people on the plain old simple Pain Meds the what I call tried and true, rather then mess us up with all these Psych/Epilepsy? neuropathic drugs that cause me and many folks I know in chonic pain, even more sorrow than we alreay have by messing with our brains that aren't really the issue, it's the physical pain that's the issue.

As long as I stay on my Pain Mgmt drugs and one decent muscle relaxer as I also have OA and Degenerative Disc Disease I feel mentally fine and have decent pain control and can actually function if I pace out my physical activities. I think the drug Co's and the Dr's need to quit pushing all these psych drugs at us.

that is my humble opinion for what it's worth and hopefully may help someone else out there!