Hello Afib!!!



Have you guys at JNJ had your first fatal gut-bleed on your new drug zarelto yet?

Nope, the FDA and NICE are looking at your 50 deaths and new kidney function test though. Pradaxa has been such a blockbuster, 6 months in new prescriptions started trailing off. Nice work BI, you can scream all you want, for your bonus of course not for the good of medicine or patients, and the fact that your drug is crap was uncovered less than a year in shows how weak you bitches really are.
 
If there are 50 deaths reported in the first year post launch, than this is quite low if one were to look at how many patients have been prescribed pradaxa..well over 400K. Do the math, and this a low occurrence especially when you consider the patient type and average mortality rates seen with warfarin and now rivaroxaban.
 
Nope, the FDA and NICE are looking at your 50 deaths and new kidney function test though. Pradaxa has been such a blockbuster, 6 months in new prescriptions started trailing off. Nice work BI, you can scream all you want, for your bonus of course not for the good of medicine or patients, and the fact that your drug is crap was uncovered less than a year in shows how weak you bitches really are.

Xarelto and Pradaxa are both dosed based on kidney function. Will doctors just guess when prescribing Xarelto? We picked the easy fruit, those left don't want a 40 to 50 dollar Medicare copay. Best of luck getting them to go 3rd and 4th tier.
 
260 deaths/over 400,000 treated equals <0.06% deaths
The average annual mortality rate in patients with atrial fibrillation is 3-5% (depending on source).

+1
 
260 deaths/over 400,000 treated equals <0.06% deaths
The average annual mortality rate in patients with atrial fibrillation is 3-5% (depending on source).

Your data is wrong....the article said 260 deaths on Pradaxa worldwide, which is more in line with 1 million RX's and NOT 400K.

The drug is an "anti-coagulant" used to treat sick people who already have a "death-cloud' hanging over their heads. An "Anticoagulant" makes this cloud smaller, but never gets rid of it. Thus, you will ALWAYS have death associated while taking these drugs regardless of the benefits these drugs give. No death is wanted but some deaths are expected on these types of drugs.

If anybody should understand about minimizing things it should be you guys at JNJ and Bayer.
 
Your data is wrong....the article said 260 deaths on Pradaxa worldwide, which is more in line with 1 million RX's and NOT 400K.

The drug is an "anti-coagulant" used to treat sick people who already have a "death-cloud' hanging over their heads. An "Anticoagulant" makes this cloud smaller, but never gets rid of it. Thus, you will ALWAYS have death associated while taking these drugs regardless of the benefits these drugs give. No death is wanted but some deaths are expected on these types of drugs.

If anybody should understand about minimizing things it should be you guys at JNJ and Bayer.
The 260 deaths were related to BLEEDS and complications (AEs) not MIs or stroke or death clouds outcomes.
 
_____________________

Discontinuing XARELTO in the absence of adequate alternative anticoagulation
increases the risk of thrombotic events. An increased rate of stroke was
observed during the transition from XARELTO to warfarin in clinical trials in atrial
fibrillation patients. If XARELTO must be discontinued for a reason other than
pathological bleeding, consider administering another anticoagulant [see
Dosage and Administration (2.1) and Clinical Studies (14.1)].
________________________

Hello Kind sirs,

I am an elderly man with a disease caused atrial fibrillation and my primary care doctor says your drug will be the best in class! I am now on your drug, but do I have to have a tooth extracated. But it tells me here that I now have to go do some drug called enoxaparin, sry I am bad with names, in order to just have my tooth extracated. I can't afford the enoxaparin now since your drug costed me half of my socials security. What should I do now, my tooth really hurt me?
 
Comming at ya AFib with a black box for death once you stop taking the drug - better hope patients on xzarelto don't need a tooth extraction, colonoscopy, or procedure, because if they stop taking it they will regret it. At least you can have dialysis to clear it out of your system - oh wait you CAN'T!



Tooth extraction= planned. Colonoscopy=planned. ACS event= NEVER planned. Moron! Take a nice look at the Atlas results. Xarelto has HUGE, game changing, guideline changing data my friend. Cardioprotective benefits on top of stroke reduction.... Pradaxa FAILED this attempt idiot (as did apixaban) I would rather deal with a bleed than be wheeled out of the hospital to a funeral home. Mortality trumps everything pal. Game over!!!
 
Tooth extraction= planned. Colonoscopy=planned. ACS event= NEVER planned. Moron! Take a nice look at the Atlas results. Xarelto has HUGE, game changing, guideline changing data my friend. Cardioprotective benefits on top of stroke reduction.... Pradaxa FAILED this attempt idiot (as did apixaban) I would rather deal with a bleed than be wheeled out of the hospital to a funeral home. Mortality trumps everything pal. Game over!!!

Doesn't matter if they can't even stop taking the drug to get a catheter placed. Listen, the only way zarelto worked for ACS was in lowest of lowest dose but had huge, huge increase in bleeding. Cardiologists will say NOT worth the risk of loosing my license with a malpractice suit by prescribing triple therapy. Also, there's no way in the world the FDA will even consider getting your drug approved for ACS. The BARELY approved you for DVT (took 4 yrs because the FDA didn't like your data) and took a political override of FDA admin to get AFib. Do you honestly think the FDA even trusts Janssen or Bayer after your "per Protocol" horse-shit.

Game-over for you.
The Dax-man
 
Doesn't matter if they can't even stop taking the drug to get a catheter placed. Listen, the only way zarelto worked for ACS was in lowest of lowest dose but had huge, huge increase in bleeding. Cardiologists will say NOT worth the risk of loosing my license with a malpractice suit by prescribing triple therapy. Also, there's no way in the world the FDA will even consider getting your drug approved for ACS. The BARELY approved you for DVT (took 4 yrs because the FDA didn't like your data) and took a political override of FDA admin to get AFib. Do you honestly think the FDA even trusts Janssen or Bayer after your "per Protocol" horse-shit.

Game-over for you.
The Dax-man

damn iPad - it's "losing" not "loosing"
 
.
.
.
Conference call on a Sunday - ATLAS....?
.
.
.

Not good one too:

End point
ICH Rivaroxaban 2.5 mg twice daily (%) v Placebo (%)
Riva Plac HR (95% CI) p
0.4 0.2 2.83 (1.02-7.86) 0.04

Bahahah, nice hazard ratio you have there for causing an intracranial hemorrhage. So, less chance of MI, but I'll be in a nursing home from a brain bleed. Great quality of life you have there on your drug. Next.
 


Write your reply...