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J&J opts out of licensing Genmab's Darzalex challenger after look at phase 1/2 data

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Johnson & Johnson is dropping a partnership with Genmab centered around a CD38 monoclonal antibody, prompting the latter company to discontinue development of the program.

Source
Fierce Biotech

Sanofi scores with its subcutaneous version of Sarclisa as it tries to play catch up with J&J's Darzalex

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Trailing Johnson & Johnson’s powerhouse Darzalex by roughly five years in its development timeline has made it challenging for Sanofi’s Sarclisa—the only other CD38 antibody on the market for multiple myeloma—to compete in the indication.

Source
Fierce Pharma

ASH: With survival win against J&J's Darzalex, GSK bolsters case for return of myeloma ADC Blenrep

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GSK’s antibody-drug conjugate Blenrep has mounted a sizable patient survival benefit among certain multiple myeloma patients in a head-to-head comparison against Johnson & Johnson’s industry-leading Darzalex.

Source
Fierce Pharma

J&J angles Darzalex for first move into early-stage myeloma with trial win, FDA filing

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After a positive phase 3 trial, Johnson & Johnson hopes its Darzalex could become the first treatment option for patients with smoldering multiple myeloma, an early-stage form of the blood disorder.

Source
Fierce Pharma

Top 40 Best-Selling Oncology Drugs in 2023 by 2022 Data

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In the dynamic landscape of oncology therapeutics, understanding the trends and performances of leading drugs is crucial for stakeholders across the healthcare and life sciences sectors. The top 40 best-selling oncology drugs in 2023, informed by 2022 sales statistics, mark significant milestones in cancer treatment and research. This analysis not only highlights the financial success of these drugs but also sheds light on the therapeutic advancements and innovation driving patient outcomes in the oncology domain.

Source
Xtalks

Genmab loses appeal in Darzalex royalties arbitration case against Johnson & Johnson

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While sales for Johnson & Johnson’s Darzalex continue to boom—as the company reported in its quarterly earnings presentation on Tuesday—the pharma major got more good news about its blockbuster multiple myeloma treatment with a victory in an arbitration case.

Source
Fierce Pharma
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ASH: J&J, Sanofi square off in newly diagnosed multiple myeloma

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Another data face-off between the two anti-CD38 multiple myeloma drugs—Johnson & Johnson’s Darzalex and Sanofi’s Sarclisa—took place at the 65th American Society of Hematology meeting. Both regimens showed strong efficacy data in newly diagnosed patients, but only one result is considered practice-changing right now.

Source
Fierce Pharma

Focus On Genmab's Pipeline If Darzalex Arbitration with Janssen Goes Sideways

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Genmab A/S decided to file a request to review the award dismissing its claims in the second arbitration arising under its license agreement with Johnson & Johnson's Janssen Biotech Inc for Darzalex (daratumumab).

Source
Benzinga